Identification of Bipotential Blood Cell/Nephrocyte Progenitors in Drosophila: Another Route for Generating Blood Progenitors

The lymph gland is the larval hematopoietic organ and is aligned along the anterior part of the cardiovascular system, composed of cardiac cells, that form the cardiac tube and its associated pericardial cells or nephrocytes. By the end of embryogenesis the lymph gland is composed of a single pair o...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in cell and developmental biology 2022-02, Vol.10, p.834720-834720
Main Authors: Morin-Poulard, Ismaël, Destalminil-Letourneau, Manon, Bataillé, Laetitia, Frendo, Jean-Louis, Lebreton, Gaëlle, Vanzo, Nathalie, Crozatier, Michèle
Format: Article
Language:English
Subjects:
blood bi-potent progenitor
Cell and Developmental Biology
Development Biology
Drosophila
Embryology and Organogenesis
hematopoiesis
Klf15
Life Sciences
lymph gland ontogeny
nephrocyte
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The lymph gland is the larval hematopoietic organ and is aligned along the anterior part of the cardiovascular system, composed of cardiac cells, that form the cardiac tube and its associated pericardial cells or nephrocytes. By the end of embryogenesis the lymph gland is composed of a single pair of lobes. Two additional pairs of posterior lobes develop during larval development to contribute to the mature lymph gland. In this study we describe the ontogeny of lymph gland posterior lobes during larval development and identify the genetic basis of the process. By lineage tracing we show here that each posterior lobe originates from three embryonic pericardial cells, thus establishing a bivalent blood cell/nephrocyte potential for a subset of embryonic pericardial cells. The posterior lobes of L3 larvae posterior lobes are composed of heterogeneous blood progenitors and their diversity is progressively built during larval development. We further establish that in larvae, homeotic genes and the transcription factor Klf15 regulate the choice between blood cell and nephrocyte fates. Our data underline the sequential production of blood cell progenitors during larval development.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2022.834720