Time to Treatment Initiation and Survival in Adult Localized High-Grade Bone Sarcoma

Objective. Few studies have evaluated the prognostic implication of the length of time from diagnosis to treatment initiation in bone sarcoma. The purpose of this study is to determine if time to treatment initiation (TTI) influences overall survival in adults diagnosed with primary bone sarcoma. Me...

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Bibliographic Details
Published in:Complexity (New York, N.Y.) N.Y.), 2020, Vol.2020 (2020), p.1-9
Main Authors: Nystrom, Lukas M., Mesko, Nathan W., Rubin, Brian P., Shepard, Dale R., Anderson, Peter M., Jin, Yuxuan, George, Jaiben, Curtis, Gannon L., Featherall, Joseph, Lawrenz, Joshua M., Reith, John D.
Format: Article
Language:English
Subjects:
Adults
Analysis
Bone cancer
Bone tumors
Cancer patients
Cancer therapies
Care and treatment
Chondrosarcoma
Committees
Diagnosis
Health care policy
Histology
Medical education
Medical prognosis
Patients
Sarcoma
Software
Survival
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Summary:Objective. Few studies have evaluated the prognostic implication of the length of time from diagnosis to treatment initiation in bone sarcoma. The purpose of this study is to determine if time to treatment initiation (TTI) influences overall survival in adults diagnosed with primary bone sarcoma. Methods. A retrospective analysis of the National Cancer Database identified 2,122 patients who met inclusion criteria with localized, high-grade bone sarcoma diagnosed between 2004 and 2012. TTI was defined as length of time in days from diagnosis to initiation of treatment. Patient, disease-specific, and healthcare-related factors were also assessed for their association with overall survival. Kruskal-Wallis analysis was utilized for univariate analysis, and Cox regression modeling identified covariates associated with overall survival. Results. Any 10-day increase in TTI was not associated with decreased overall survival (hazard ratio (HR) = 1.00; P=0.72). No differences in survival were detected at 1 year, 5 years, and 10 years, when comparing patients with TTI = 14, 30, 60, 90, and 150 days. Decreased survival was significantly associated P 71 years (HR = 2.89; P
ISSN:1076-2787
1357-714X
1099-0526
1369-1643
DOI:10.1155/2020/2984043