The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA

The product of Physician Global Assessment and Body Surface Area (PGA × BSA) is a new outcome measure for psoriasis severity and response to therapy. The objective of this study was to evaluate PGA × BSA as an alternative to Psoriasis Area and Severity Index (PASI) for psoriasis assessments. The rel...

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Bibliographic Details
Published in:Psoriasis (Auckland, New Zealand) New Zealand), 2018-01, Vol.8, p.65-74
Main Authors: Walsh, Jessica A, Jones, Heather, Mallbris, Lotus, Duffin, Kristina Callis, Krueger, Gerald G, Clegg, Daniel O, Szumski, Annette
Format: Article
Language:English
Subjects:
agreement
Agreements
Backup software
Clinical medicine
Clinical trials
correlation
Dermatology
Drugs
Etanercept
Original Research
PASI
Patients
PGAxBSA
Psoriasis
Quality of life
responsiveness
Skin
Systematic review
Values
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Summary:The product of Physician Global Assessment and Body Surface Area (PGA × BSA) is a new outcome measure for psoriasis severity and response to therapy. The objective of this study was to evaluate PGA × BSA as an alternative to Psoriasis Area and Severity Index (PASI) for psoriasis assessments. The relationship between PASI and PGA × BSA was assessed in a post hoc analysis of pooled data from the PRISTINE (NCT00663052) and PRESTA (NCT00245960) trials in patients with moderate-to-severe psoriasis who received etanercept 50 mg/week. Data were analyzed using Spearman and intra-class correlation coefficients, effect sizes, scatterplots, Bland-Altman plots, and Kappa statistics. Spearman correlations at baseline, week 12, and week 24 were strong for PGA × BSA versus PASI ( =0.78, 0.87, and 0.90, respectively; all
ISSN:2230-326X
2230-326X
DOI:10.2147/PTT.S169333