Complex Relationships between HIV-1 Integrase and Its Cellular Partners

RNA viruses, in pursuit of genome miniaturization, tend to employ cellular proteins to facilitate their replication. HIV-1, one of the most well-studied retroviruses, is not an exception. There is numerous evidence that the exploitation of cellular machinery relies on nucleic acid-protein and protei...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-10, Vol.23 (20), p.12341
Main Authors: Rozina, Anna, Anisenko, Andrey, Kikhai, Tatiana, Silkina, Maria, Gottikh, Marina
Format: Article
Language:English
Subjects:
cellular partners
Enzymes
Genomes
HIV-1
Infections
Integrase
Miniaturization
Morphogenesis
Mutation
Nef protein
Nucleic acids
Protein interaction
Proteins
Review
RNA viruses
Vpr protein
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Summary:RNA viruses, in pursuit of genome miniaturization, tend to employ cellular proteins to facilitate their replication. HIV-1, one of the most well-studied retroviruses, is not an exception. There is numerous evidence that the exploitation of cellular machinery relies on nucleic acid-protein and protein-protein interactions. Apart from Vpr, Vif, and Nef proteins that are known to regulate cellular functioning via interaction with cell components, another viral protein, integrase, appears to be crucial for proper virus-cell dialog at different stages of the viral life cycle. The goal of this review is to summarize and systematize existing data on known cellular partners of HIV-1 integrase and their role in the HIV-1 life cycle.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232012341