Whole-Genome Sequencing of Salmonella Mississippi and Typhimurium Definitive Type 160, Australia and New Zealand

We used phylogenomic and risk factor data on isolates of Salmonella enterica serovars Mississippi and Typhimurium definitive type 160 (DT160) collected from human, animal, and environmental sources to elucidate their epidemiology and disease reservoirs in Australia and New Zealand. Sequence data sug...

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Bibliographic Details
Published in:Emerging infectious diseases 2019-09, Vol.25 (9), p.1690-1697
Main Authors: Ford, Laura, Ingle, Danielle, Glass, Kathryn, Veitch, Mark, Williamson, Deborah A, Harlock, Michelle, Gregory, Joy, Stafford, Russell, French, Nigel, Bloomfield, Samuel, Grange, Zoe, Conway, Mary Lou, Kirk, Martyn D
Format: Article
Language:English
Subjects:
Animals
Animals, Wild
Australia - epidemiology
Bacterial genetics
Disease Reservoirs
DNA sequencing
Epidemiology
Genetic aspects
Genetic polymorphisms
Genomes
Genomics
Health aspects
Humans
Mississippi and Typhimurium Definitive Type 160, Australia and New Zealand
New Zealand - epidemiology
Reservoirs (Water)
Salmonella
Salmonella enterica - genetics
Salmonella Infections - epidemiology
Salmonella Infections - microbiology
Salmonella typhimurium
Salmonella typhimurium - genetics
Single nucleotide polymorphisms
Travel
Travelers
Whole Genome Sequencing
Whole-Genome Sequencing of
Wildlife
Zoonoses
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Summary:We used phylogenomic and risk factor data on isolates of Salmonella enterica serovars Mississippi and Typhimurium definitive type 160 (DT160) collected from human, animal, and environmental sources to elucidate their epidemiology and disease reservoirs in Australia and New Zealand. Sequence data suggested wild birds as a likely reservoir for DT160; animal and environmental sources varied more for Salmonella Mississippi than for Salmonella Typhimurium. Australia and New Zealand isolates sat in distinct clades for both serovars; the median single-nucleotide polymorphism distance for DT160 was 29 (range 8-66) and for Salmonella Mississippi, 619 (range 565-737). Phylogenomic data identified plausible sources of human infection from wildlife and environmental reservoirs and provided evidence supporting New Zealand-acquired DT160 in a group of travelers returning to Australia. Wider use of real-time whole-genome sequencing in new locations and for other serovars may identify sources and routes of transmission, thereby aiding prevention and control.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2509.181811