Camel filariasis (Dipetalonema evansi) and its association with clinical balanoposthitis with reference to prominent changes in clinical findings, serum testosterone, semen analysis, and testicular histopathology

• Published in: BMC veterinary research 2024-01, Vol.20 (1), p.1-1, Article 1
• Main Authors: Khalphallah, Arafat, Al-Daek, Taher, Abdelhamid, Mahmoud, Elmeligy, Enas, El-Hawari, Sayed Fathi, Khesruf, Khaled A, Nasr, Heba A, Mohamed, Ragab H
• Format: Article
• Language: English
• Subjects: adults; Analysis; Animals; Balanoposthitis; Blood; blood cell counts; blood serum; Camelidae; Camelids; camels; Care and treatment; Clinical findings; Corticosteroids; Cortisol; Diagnosis; Dipetalonema; Ethylenediaminetetraacetic acid; fever; Filariasis; Health aspects; Histochemistry; Histology, Pathological; Histopathology; Hormones; Infections; Male camels; males; Manures; Measurement; Medical research; Medicine, Experimental; Methylene blue; microscopy; Mosquitoes; Nematoda; Parasites; Parasitic diseases; Risk factors; Seasons; Semen; Skin; Skin tests; Sperm; Sperm vitality and abnormalities; spermatozoa; Testes; Testosterone
• ISSN: 1746-6148; 1746-6148
• DOI: 10.1186/s12917-023-03844-5

Camel filariasis induced variable clinical syndromes characterized by fever, lethargy, localized dermal lesions, loss of condition, and testicular and scrotal swelling. The objective of the present work focused on clarifying the diagnostic importance of clinical findings, serum testosterone, and semen analysis as well as blood smear and testicular histopathology as a differential tool between only balanoposthitis without filariasis male camels group (OnlyBp ) and balanoposthitis-filariasis infected male camels group (BpFl ). The study also monitored the associations between the severity of ticks' infestations in investigated male camels and the occurrence of balanoposthitis only or balanoposthitis with filariasis. The study reported significant correlation between serum testosterone, serum cortisol, and sperm vitality and abnormalities percentages. The study included male camels (n = 250) classified into three groups: healthy control group (Cont ; n = 30), OnlyBp (n = 210), and BpFl (n = 10). These male camels were clinically and laboratory examined, and skin scraping tests and testicular histopathology were conducted. The study confirmed the association of the changes in clinical findings, whole blood picture, serum testosterone, serum cortisol, and semen analysis, with OnlyBp and BpFl . These changes were more prominent in BpFl than in OnlyBp . Skin scraping test results revealed a higher severity of live ticks' infestation in BpFl than in OnlyBp because, unlike OnlyBp , all camels in BpFl (n = 10) were suffering from live ticks' infestation. It also concluded the higher efficacy of histopathology of testicular tissues in male camels as a diagnostic tool for adult filaria in balanoposthitis-affected male camels than blood smear because all cases of camel filariasis in the current work were negative for microfilaria on microscopic examination of diurnal blood smear as well as testicular histopathology revealed detection of adult filaria in all camel filariasis associated with balanoposthitis. Strong correlation relationships were demonstrated between serum testosterone, serum cortisol, and semen analysis results. Positive correlations were reported between serum testosterone levels and sperm vitality percentages. However, negative correlations were stated between serum testosterone and each of serum cortisol and sperm abnormalities either in Cont , OnlyBp or BpFl .