Clinical significance of urinary L-FABP in the emergency department

Background This study’s aim is to measure liver-type fatty acid-binding protein (L-FABP) levels in urine using a rapid semiquantitative assay kit in the emergency department and to investigate whether the onset of acute kidney injury (AKI) after hospitalization can be predicted. Methods This was a p...

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Bibliographic Details
Published in:International journal of emergency medicine 2019-08, Vol.12 (1), p.1-7, Article 24
Main Authors: Suzuki, Ginga, Ichibayashi, Ryo, Yamamoto, Saki, Nakamichi, Yoshimi, Watanabe, Masayuki, Honda, Mitsuru
Format: Article
Language:English
Subjects:
Acute kidney injury
AKI
Angiology
Cardiology
Clinical outcomes
Clinical significance
Emergency medical care
Emergency Medicine
Fatty acids
Health risk assessment
Hospitalization
Internal Medicine
Kidneys
L-FABP
Liver-type fatty acid-binding protein
Medicine
Medicine & Public Health
Original Research
Pediatrics
Urinalysis
Urine
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Summary:Background This study’s aim is to measure liver-type fatty acid-binding protein (L-FABP) levels in urine using a rapid semiquantitative assay kit in the emergency department and to investigate whether the onset of acute kidney injury (AKI) after hospitalization can be predicted. Methods This was a prospective observation study. Patients transferred to the emergency and critical care center were divided into two groups: urinary L-FABP negative and positive groups. The status and severity of AKI were evaluated for the respective patients based on the Kidney Disease: Improving Global Outcome (KDIGO) classification. We compared the proportion of AKI patients in the two groups. Results In the urine L-FABP-positive group, many patients had a significant onset of AKI ( p  
ISSN:1865-1372
1865-1380
DOI:10.1186/s12245-019-0244-9