Evaluation of Antiulcer Activity of Peltophorum Pterocarpum

is a rich source for phenols and the wood, leaves, and flowers of the plant are used as medicinal agents in traditional medicine. Peptic ulcer is a major disease of gastrointestinal tract, affecting nearly 40 lac people each year worldwide and affects 10% of world population with different aetiologi...

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Bibliographic Details
Published in:Journal of clinical and diagnostic research 2017-06, Vol.11 (6), p.FF01-FF03
Main Authors: Pradeepkumar, Bhupalam, Bhavyamadhuri, C P, Padmanabhareddy, Y, Veerabhadrappa, K V, Narayana, Gorantla, Haranath, C, Somasekharreddy, K, Sudheer, Akkiraju
Format: Article
Language:English
Subjects:
indomethacin
misoprostol
Pharmacology Section
pylorus ligation
ulcer index
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Summary:is a rich source for phenols and the wood, leaves, and flowers of the plant are used as medicinal agents in traditional medicine. Peptic ulcer is a major disease of gastrointestinal tract, affecting nearly 40 lac people each year worldwide and affects 10% of world population with different aetiologies. consists of phenols and flavonoids, tannins which have potential antioxidant and cytoprotective activity. To evaluate the antiulcer activity of methanolic extract of the leaves of (MEPP) on albino rats. The rats were divided into four groups as control, standard, test 1 (extract: 100 mg/kg) and test 2 (extract: 200 mg/kg) with six rats in each group. Gastric lesions were induced by oral administration of indomethacin (20 mg/kg) followed by pylorus ligation. Standard group of animals were treated with misoprostol and test group of animals were treated with MEPP at doses of 100 and 200 mg/kg. To determine the antiulcer activity of extract, mean ulcer index, free acidity and total acidity were evaluated. Ulcer index was significantly decreased at p
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2017/26171.9998