Clinical significance of PCT, CRP, IL-6, NLR, and TyG Index in early diagnosis and severity assessment of acute pancreatitis: A retrospective analysis

• Published in: Scientific reports 2025-01, Vol.15 (1), p.2924-10, Article 2924
• Main Authors: Xinyu, Xu, Jiang, Zhou, Qing, Ai, Lihua, Li, Xiehong, Liu, Lin, Zhou
• Format: Article
• Language: English
• Subjects: 692/53; 692/699; Acute Disease; Acute Pancreatitis (AP); Adult; Aged; Biomarkers; Biomarkers - blood; C-Reactive protein (CRP); C-Reactive Protein - analysis; C-Reactive Protein - metabolism; Clinical Relevance; Diagnosis; Early Diagnosis; Female; Humanities and Social Sciences; Humans; Hyperlipidemia; Interleukin 6; Interleukin-6 (IL-6); Interleukin-6 - blood; Male; Middle Aged; multidisciplinary; Multivariate analysis; Neutrophil-to-lymphocyte ratio (NLR); Neutrophils - metabolism; Pancreatitis; Pancreatitis - blood; Pancreatitis - diagnosis; Patients; Procalcitonin (PCT); Procalcitonin - blood; Retrospective Studies; ROC Curve; Science; Science (multidisciplinary); Severity of Illness Index; Triglyceride-glucose index (TyG Index)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-025-86664-x

To evaluate the clinical utility of PCT, CRP, IL-6, NLR, and TyG index in improving the early diagnosis and severity assessment of acute pancreatitis (AP). This retrospective study included 137 AP patients and 30 healthy controls from Hunan Provincial People’s Hospital (January 2021–September 2023). Univariate and multivariate logistic regression analyses assessed the associations between biomarkers and severe acute pancreatitis (SAP). Receiver operating characteristic (ROC) curves, DeLong test, and Bonferroni correction were used to evaluate predictive performance. Model robustness was validated via 5-fold cross-validation. PCT, CRP, IL-6, NLR, and TyG index levels were significantly elevated in AP patients compared to controls ( P