Antiplasmodial Activity of Hydroalcoholic Extract from Jucá ( Libidibia ferrea ) Pods

Malaria is an infectious and parasitic disease caused by protozoa of the genus , which affects millions of people in tropical and subtropical areas. Recently, there have been multiple reports of drug resistance in populations, leading to the search for potential new active compounds against the para...

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Bibliographic Details
Published in:Pharmaceutics 2023-04, Vol.15 (4), p.1162
Main Authors: Assis, Francisco Flávio Vieira de, Almeida Junior, José Sousa de, Moraes, Tânia Mara Pires, Varotti, Fernando de Pilla, Moraes, Camila Castilho, Sartoratto, Adilson, Moraes, Waldiney Pires, Minervino, Antonio Humberto Hamad
Format: Article
Language:English
Subjects:
Alcohol
Amazon
Antimalarials
Blood
Cells
Cryopreservation
Cytotoxicity
Drug dosages
herbal medicines
Jucá
Malaria
Medicine, Botanic
Medicine, Herbal
Parasites
Software
Testing
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Summary:Malaria is an infectious and parasitic disease caused by protozoa of the genus , which affects millions of people in tropical and subtropical areas. Recently, there have been multiple reports of drug resistance in populations, leading to the search for potential new active compounds against the parasite. Thus, we aimed to evaluate the in vitro antiplasmodial activity and cytotoxicity of the hydroalcoholic extract of Jucá ( in serial concentrations. Jucá was used in the form of a freeze-dried hydroalcoholic extract. For the cytotoxicity assay, the(3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) method with the WI-26VA4 human cell line was used. For the antiplasmodial activity, synchronized cultures were treated with serial concentrations (0.2 to 50 μg/mL) of the Jucá extract. In terms of the chemical composition of the Jucá extract, gas chromatography coupled to mass spectrometry measurements revealed the main compounds as ellagic acid, valoneic acid dilactone, gallotannin, and gallic acid. The Jucá hydroalcoholic extract did not show cytotoxic activity per MTT, with an IC value greater than 100 µg/mL. Regarding the antiplasmodial activity, the Jucá extract presented an IC of 11.10 µg/mL with a selective index of nine. Because of its antiplasmodial activity at the tested concentrations and low toxicity, the Jucá extract is presented as a candidate for herbal medicine in the treatment of malaria. To the best of our knowledge, this is the first report of antiplasmodial activity in Jucá.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15041162