Association of vitamin D receptor gene polymorphisms with risk of cutaneous melanoma. A meta-analysis based on 40 case-control studies

• Published in: Przegląd dermatologiczny 2019-01, Vol.106 (3), p.268-279
• Main Authors: Niktabar, Seyed Mohammadreza, Latifi, Seyed Mojtaba, Moghimi, Mansour, Jafari-Nedooshan, Jamal, Aghili, Kazem, Mohsen Miresmaeili, Seyed, Zare-Shehneh, Masoud, Neamatzadeh, Hossein
• Format: Article
• Language: English
• Subjects: cutaneous melanoma; Health risk assessment; Melanoma; Meta-analysis; polymorphism; Vitamin D; vitamin d receptor
• ISSN: 0033-2526; 2084-9893
• DOI: 10.5114/dr.2019.86909

Introduction Previous studies on the association of vitamin D receptor (VDR) gene polymorphisms with cutaneous melanoma risk reported conflicting results. Objective To obtain a more precise assessment of the associations, we performed a meta-analysis of previously published studies. Material and methods We searched for eligible studies in the PubMed, Embase, and CNKI databases. A total of 40 case-control studies with 1,144 cases and 2,925 controls were included. Results The pooled analyses suggested a significant association between the FokI C>T and BsmI G>A polymorphisms of the VDR gene and susceptibility to melanoma. However, we found that the VDR TaqI T>C, EcoRV A>G, ApaI G>T, and Cdx2 G>A polymorphisms were not associated with melanoma risk. Conclusions The meta-analysis suggests that VDR FokI C>T and BsmI G>A polymorphisms are significantly associated with melanoma risk, while TaqI T>C, EcoRV A>G, ApaI G>T, and Cdx2 G>A polymorphisms are not associated with melanoma risk.