Altrenogest Supplementation during Early Pregnancy Improves Reproductive Outcome in Pigs

Progesterone plays an important role in initial conceptus development and in a successful pregnancy, but results related to progesterone or its analogues (altrenogest) supplementation in early pregnancy of pigs are conflicting. The present study evaluated the effects of altrenogest supplementation i...

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Bibliographic Details
Published in:Animals (Basel) 2022-07, Vol.12 (14), p.1801
Main Authors: Muro, Bruno Bracco Donatelli, Oliveira, Ana Clara Rodrigues, Carnevale, Rafaella Fernandes, Leal, Diego Feitosa, Monteiro, Matheus Saliba, Poor, André Pegoraro, Pereira, Francisco Alves, de Souza, Leury Jesus, Ferreira, Juliana Bonin, Almond, Glen William, Garbossa, Cesar Augusto Pospissil
Format: Article
Language:English
Subjects:
Animals
Birth weight
Childbirth & labor
Cytokines
Economics
Embryos
Endometrium
Females
Gene expression
gestation
Growth factors
Hogs
Intensive farming
Low birth weight
Nutrients
Ovulation
Placenta
Pregnancy
Progesterone
Reproduction
Stillbirth
Swine
Swine production
Uterus
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Summary:Progesterone plays an important role in initial conceptus development and in a successful pregnancy, but results related to progesterone or its analogues (altrenogest) supplementation in early pregnancy of pigs are conflicting. The present study evaluated the effects of altrenogest supplementation in sows during days 6 and 12 of pregnancy on reproductive performance. On day 6 of pregnancy, 301 females were allocated at random to one of the following treatments: CON (Control: non-supplemented females, n = 163) or ALT (females daily supplemented with 20 mg of altrenogest, orally, from day 6 to 12 of pregnancy, n = 138). Ovulation was considered as occurred at 48 h after the first estrus detection to standardize the first day of pregnancy. The supplementation increased the number of total piglets born (ALT: 17.3 ± 0.4; CON: 16.6 ± 0.4), piglets born alive (ALT: 15.6 ± 0.4; CON: 14.8 ± 0.3), and placenta weight (ALT: 4.2 ± 0.1; CON: 3.8 ± 0.1) and decreased the stillbirth rate (ALT: 5.9 ± 0.6; CON: 7.6 ± 0.6) and the number of piglets born weighing less than 800 g (ALT: 6.6 ± 0.6; CON: 8.0 ± 0.6), without impairment on farrowing rate. These results demonstrated that altrenogest supplementation on swine females between days 6 and 12 of pregnancy may be used to improve reproductive performance.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani12141801