A High-Yielding Synthesis of the Naturally Occurring Antitumour Agent Irisquinone

A short, high-yielding synthesis of the antitumour agent irisquinone (1) is described. The key steps are the palladium catalysed coupling reaction of dec-9-yn-1-ol with iodide (2) to form alkyne (3) and the Fremy's salt oxidation of phenol (7).

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Bibliographic Details
Published in:MolBank 2000-01, Vol.5 (1), p.82-88
Main Authors: Hadfield, John A, McGown, Alan T, Butler, John
Format: Article
Language:English
Subjects:
Alcohol
antitumour
Chinese medicine
Irisquinone
Laboratories
Medical research
Oxidation
Palladium
Phenols
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Description
Summary:A short, high-yielding synthesis of the antitumour agent irisquinone (1) is described. The key steps are the palladium catalysed coupling reaction of dec-9-yn-1-ol with iodide (2) to form alkyne (3) and the Fremy's salt oxidation of phenol (7).
ISSN:1420-3049
1420-3049
1422-8599
DOI:10.3390/50100082