Non-eosinophilic asthma: current perspectives

Although non-eosinophilic asthma (NEA) is not the best known and most prevalent asthma phenotype, its importance cannot be underestimated. NEA is characterized by airway inflammation with the absence of eosinophils, subsequent to activation of non-predominant type 2 immunologic pathways. This phenot...

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Bibliographic Details
Published in:Journal of asthma and allergy 2018-01, Vol.11, p.267-281
Main Authors: Esteban-Gorgojo, Ignacio, Antolín-Amérigo, Darío, Domínguez-Ortega, Javier, Quirce, Santiago
Format: Article
Language:English
Subjects:
Adults
Airway management
Allergies
Asthma
asthma endotype
asthma phenotype
Biopsy
Cell activation
Chronic obstructive pulmonary disease
Cigarettes
Corticosteroid drugs
Corticosteroids
Genotype & phenotype
Infection
Inflammation
Kinases
Leukocytes (eosinophilic)
neutrophilic asthma
Neutrophils
non-eosinophilic asthma
Obesity
Phenotypes
Pollution
Respiratory system agents
Respiratory tract
Respiratory tract diseases
Review
Risk factors
Smoking
Sputum
Steroids (Organic compounds)
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Description
Summary:Although non-eosinophilic asthma (NEA) is not the best known and most prevalent asthma phenotype, its importance cannot be underestimated. NEA is characterized by airway inflammation with the absence of eosinophils, subsequent to activation of non-predominant type 2 immunologic pathways. This phenotype, which possibly includes several not well-defined subphenotypes, is defined by an eosinophil count
ISSN:1178-6965
1178-6965
DOI:10.2147/JAA.S153097