Cinnamon Oil Alleviates Acetaminophen-Induced Uterine Toxicity in Rats by Abrogation of Oxidative Stress, Apoptosis, and Inflammation

Paracetamol, or acetaminophen (APAP), is one of the first-line medications that is used for fever and pain. However, APAP can induce uterine toxicity when overused. The mode of action of APAP toxicity is due to the production of free radicals. The main goal of our study is to determine uterine toxic...

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Bibliographic Details
Published in:Plants (Basel) 2023-06, Vol.12 (12), p.2290
Main Authors: Hussain, Sohail, Alshahrani, Saeed, Siddiqui, Rahimullah, Khan, Andleeb, Elhassan Taha, Manal Mohammed, Ahmed, Rayan A, Jali, Abdulmajeed M, Qadri, Marwa, Khairat, Khairat H M, Ashafaq, Mohammad
Format: Article
Language:English
Subjects:
Acetaminophen
Analgesics
Antioxidants
Apoptosis
Chemical properties
Cinnamon
cinnamon oil
Cytokines
Drug dosages
Drugs
Enzymes
Essences and essential oils
Free radicals
Free radicals (Chemistry)
Health aspects
Histopathology
Inflammation
inflammation and apoptosis
Interleukin 1
Interleukin 6
Interleukins
Lipid peroxidation
Lipids
Liver
Metabolism
Metabolites
Mode of action
Oil
Overdose
Oxidative stress
Paracetamol
Parameters
Peroxidation
Testing
Toxicity
uterine toxicity
Uterus
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Summary:Paracetamol, or acetaminophen (APAP), is one of the first-line medications that is used for fever and pain. However, APAP can induce uterine toxicity when overused. The mode of action of APAP toxicity is due to the production of free radicals. The main goal of our study is to determine uterine toxicity from APAP overdose and the antioxidative activity of cinnamon oil (CO) in female rats. The effect of different doses of CO (50-200 mg/kg b.w.) was assessed in the uterus toxicity induced by APAP. Additionally, the imbalance in oxidative parameters, interleukins, and caspases was evaluated for the protective effects of CO. A single dose of APAP (2 g/kg b.w.) resulted in uterus toxicity, indicated by a significant increase in the level of lipid peroxidation (LPO), inflammatory interleukins cytokines (IL-1 and 6), expression of caspases 3 and 9, and a marked change in uterus tissue architecture evaluated by histopathology. Co-treatment of CO resulted in a significant amelioration of all the parameters such as LPO, interleukins IL-1β, IL-6, caspases 3 and 9 expression, and distortion of tissue architecture in a dose-dependent manner. Therefore, we can conclude that APAP-induced uterine injury due to oxidative stress can be restored by co-treatment with cinnamon oil (CO).
ISSN:2223-7747
2223-7747
DOI:10.3390/plants12122290