Defensive role of Rosmarinus officinalis in carbon tetrachloride-induced nephrotoxicity and oxidative stress in rats

Background There is a growing demand for remedies from natural sources to substitute synthetic therapeutic drugs and minimize their side effects and toxicity. The present study aims to evaluate the defensive ability of an ethanolic extract of Rosmarinus officinalis L. in carbon tetrachloride (CCl 4...

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Bibliographic Details
Published in:Bulletin of the National Research Centre 2019-03, Vol.43 (1), p.1-10, Article 50
Main Authors: Akram, Mir Ajaz, Tembhre, Manju, Jabeen, Ruqaya, Khalid, Shah, Sheikh, Muzafar Ahmad, Jan, Aasia, Farooq, Umer, Amin, Mohmad
Format: Article
Language:English
Subjects:
Biomarkers
Body weight
Carbon
Carbon tetrachloride
Catalase
Creatinine
Distilled water
Free radicals
Glutathione
Glutathione peroxidase
Histopathology
Humanities and Social Sciences
Kidneys
multidisciplinary
Nephrotoxicity
Olive oil
Oxidative stress
Peroxidase
Rat
Rosmarinus officinalis
Science
Science (multidisciplinary)
Side effects
Superoxide dismutase
Toxicity
Urea
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Summary:Background There is a growing demand for remedies from natural sources to substitute synthetic therapeutic drugs and minimize their side effects and toxicity. The present study aims to evaluate the defensive ability of an ethanolic extract of Rosmarinus officinalis L. in carbon tetrachloride (CCl 4 )-induced nephrotoxicity in male albino rats. Materials and methods Thirty-six rats were divided into 6 groups ( n  = 6). Group I (control) received distilled water for 30 days orally. Nephrotoxicity was induced by CCl 4 (11% v / v with olive oil, i.p) 2 ml/kg body weight (b.wt.) in group II once a week for 30 days. Groups III and IV received the only herb in two doses 100 and 250 mg/kg of b.wt. respectively. Groups V and VI received an ethanolic extract of Rosmarinus officinalis (EERO, 100 and 250 mg/kg of b.wt.) along with 2 ml/kg b.wt. CCl 4 weekly for 30 days. Results CCl 4 treatment induced highly significant ( P  
ISSN:2522-8307
2522-8307
DOI:10.1186/s42269-019-0092-z