Paclitaxel-Loaded Magnetic Nanoparticles Based on Biotinylated N-Palmitoyl Chitosan: Synthesis, Characterization and Preliminary In Vitro Studies

A considerable interest in cancer research is represented by the development of magnetic nanoparticles based on biofunctionalized polymers for controlled-release systems of hydrophobic chemotherapeutic drugs targeted only to the tumor sites, without affecting normal cells. The objective of the paper...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-06, Vol.26 (11), p.3467
Main Authors: Ursachi, Vlad Constantin, Dodi, Gianina, Rusu, Alina Gabriela, Mihai, Cosmin Teodor, Verestiuc, Liliana, Balan, Vera
Format: Article
Language:English
Subjects:
Biotin
Cancer
Cancer research
Chitosan
Controlled release
drug delivery
Hydrophobicity
In vivo methods and tests
Magnetic cores
magnetic nanoparticles
Magnetic properties
Magnetic saturation
Magnetite
Medical research
Morphology
Nanocomposites
Nanoparticles
Oxidation
Paclitaxel
Polymers
Size distribution
Tumors
viability assay
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Summary:A considerable interest in cancer research is represented by the development of magnetic nanoparticles based on biofunctionalized polymers for controlled-release systems of hydrophobic chemotherapeutic drugs targeted only to the tumor sites, without affecting normal cells. The objective of the paper is to present the synthesis and in vitro evaluation of the nanocomposites that include a magnetic core able to direct the systems to the target, a polymeric surface shell that provides stabilization and multi-functionality, a chemotherapeutic agent, Paclitaxel (PTX), and a biotin tumor recognition layer. To our best knowledge, there are no studies concerning development of magnetic nanoparticles obtained by partial oxidation, based on biotinylated N-palmitoyl chitosan loaded with PTX. The structure, external morphology, size distribution, colloidal and magnetic properties analyses confirmed the formation of well-defined crystalline magnetite conjugates, with broad distribution, relatively high saturation magnetization and irregular shape. Even if the ability of the nanoparticles to release the drug in 72 h was demonstrated, further complex in vitro and in vivo studies will be performed in order to validate the magnetic nanoparticles as PTX delivery system.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26113467