Individual differences in delay discounting are associated with dorsal prefrontal cortex connectivity in children, adolescents, and adults

• Published in: Developmental cognitive neuroscience 2023-08, Vol.62, p.101265-101265, Article 101265
• Main Authors: Mehta, Kahini, Pines, Adam, Adebimpe, Azeez, Larsen, Bart, Bassett, Danielle S., Calkins, Monica E., Baller, Erica B., Gell, Martin, Patrick, Lauren M., Shafiei, Golia, Gur, Raquel E., Gur, Ruben C., Roalf, David R., Romer, Daniel, Wolf, Daniel H., Kable, Joseph W., Satterthwaite, Theodore D.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Brain; Brain Mapping - methods; Child; Connectome; Delay Discounting; DMN; FMRI; Functional connectivity; Humans; Individuality; Magnetic Resonance Imaging; Neural Pathways; Original Research; Prefrontal Cortex; Resting-state; Youth
• ISSN: 1878-9293; 1878-9307
• DOI: 10.1016/j.dcn.2023.101265

Delay discounting is a measure of impulsive choice relevant in adolescence as it predicts many real-life outcomes, including obesity and academic achievement. However, resting-state functional networks underlying individual differences in delay discounting during youth remain incompletely described. Here we investigate the association between multivariate patterns of functional connectivity and individual differences in impulsive choice in a large sample of children, adolescents, and adults. A total of 293 participants (9–23 years) completed a delay discounting task and underwent 3T resting-state fMRI. A connectome-wide analysis using multivariate distance-based matrix regression was used to examine whole-brain relationships between delay discounting and functional connectivity. These analyses revealed that individual differences in delay discounting were associated with patterns of connectivity emanating from the left dorsal prefrontal cortex, a default mode network hub. Greater delay discounting was associated with greater functional connectivity between the dorsal prefrontal cortex and other default mode network regions, but reduced connectivity with regions in the dorsal and ventral attention networks. These results suggest delay discounting in children, adolescents, and adults is associated with individual differences in relationships both within the default mode network and between the default mode and networks involved in attentional and cognitive control. •Dorsal PFC (dPFC) connectivity is related to differences in delay discounting.•Increased dPFC-DMN connectivity is linked to higher rates of delay discounting.•Decreased dPFC-attention network connectivity is linked to more delay discounting.