Synthesis of New Highly Functionalized 1H-Indole-2-carbonitriles via Cross-Coupling Reactions

An approach for the preparation of polysubstituted indole-2-carbonitriles through a cross-coupling reaction of compounds 1-(but-2-ynyl)-1H-indole-2-carbonitriles and 1-benzyl-3-iodo-1H-indole-2-carbonitriles is described. The reactivity of indole derivatives with iodine at position 3 was studied usi...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-08, Vol.26 (17), p.5287
Main Authors: Hrizi, Asma, Cailler, Manon, Romdhani-Younes, Moufida, Carcenac, Yvan, Thibonnet, Jérôme
Format: Article
Language:English
Subjects:
1H-indole-2-carbonitriles
Alzheimer's disease
Chemical reactions
Chromatography
Couplings
Cross coupling
Heck
Indoles
Iodine
Kinases
Ligands
Palladium
Sonogashira
Stille
Suzuki–Miyaura
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Summary:An approach for the preparation of polysubstituted indole-2-carbonitriles through a cross-coupling reaction of compounds 1-(but-2-ynyl)-1H-indole-2-carbonitriles and 1-benzyl-3-iodo-1H-indole-2-carbonitriles is described. The reactivity of indole derivatives with iodine at position 3 was studied using cross-coupling reactions. The Sonogashira, Suzuki–Miyaura, Stille and Heck cross-couplings afforded a variety of di-, tri- and tetra-substituted indole-2-carbonitriles.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26175287