Antiviral Activities of Silymarin and Derivatives

Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective functions. Recent studies have also documented the antiviral activities of silymarin and its derivatives against several viruses, including the flaviviruses (hepatitis C virus...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2019-04, Vol.24 (8), p.1552
Main Authors: Liu, Ching-Hsuan, Jassey, Alagie, Hsu, Hsin-Ya, Lin, Liang-Tzung
Format: Article
Language:English
Subjects:
antiviral
Dengue fever
Drug development
Drug resistance
Epidemics
flavonolignans
Hepatitis
Hepatitis B
Hepatitis C
Infections
Infectious diseases
Inflammation
Influenza
Pathogens
Phytochemicals
Proteins
Review
RNA polymerase
Silymarin
Vaccines
Vector-borne diseases
Viral infections
Viruses
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Description
Summary:Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective functions. Recent studies have also documented the antiviral activities of silymarin and its derivatives against several viruses, including the flaviviruses (hepatitis C virus and dengue virus), togaviruses (Chikungunya virus and Mayaro virus), influenza virus, human immunodeficiency virus, and hepatitis B virus. This review will describe some of the latest preclinical and clinical studies detailing the antiviral profiles of silymarin and its derivatives, and discuss their relevance for antiviral drug development.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24081552