Premedication practices for delivery room intubations in premature infants in France: Results from the EPIPAGE 2 cohort study

To assess premedication practices before tracheal intubation of premature newborns in the delivery room (DR). From the national population-based prospective EPIPAGE 2 cohort in 2011, we extracted all live born preterms intubated in the DR in level-3 centers, without subsequent circulatory resuscitat...

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Bibliographic Details
Published in:PloS one 2019-04, Vol.14 (4), p.e0215150-e0215150
Main Authors: Walter-Nicolet, Elizabeth, Courtois, Emilie, Milesi, Christophe, Ancel, Pierre-Yves, Beuchée, Alain, Tourneux, Pierre, Benhammou, Valérie, Carbajal, Ricardo, Durrmeyer, Xavier
Format: Article
Language:English
Subjects:
Anesthesia
Apgar score
Biology and Life Sciences
Birth Weight
Bradycardia
Cohort Studies
Complications and side effects
Delivery (Childbirth)
Delivery Rooms
Female
France - epidemiology
Gestational Age
Health aspects
Human health and pathology
Humans
Infant, Newborn
Infant, Premature, Diseases - epidemiology
Infant, Premature, Diseases - prevention & control
Infants
Intubation
Intubation, Intratracheal
Life Sciences
Male
Medicine and Health Sciences
Midazolam
Midazolam - therapeutic use
Morbidity
Newborn infants
Pediatrics
Physical Sciences
Pregnancy
Premature infants
Premedication - methods
Pulmonology and respiratory tract
Research and Analysis Methods
Retrospective Studies
Risk Factors
Santé publique et épidémiologie
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Summary:To assess premedication practices before tracheal intubation of premature newborns in the delivery room (DR). From the national population-based prospective EPIPAGE 2 cohort in 2011, we extracted all live born preterms intubated in the DR in level-3 centers, without subsequent circulatory resuscitation. Studied outcomes included the rate and type of premedication, infants' and maternities' characteristics and survival and major neonatal morbidities at discharge from hospital. Univariate and multivariate analysis were performed and a generalized estimating equation was used to identify factors associated with premedication use. Out of 1494 included neonates born in 65 maternities, 76 (5.1%) received a premedication. Midazolam was the most used drug accounting for 49% of the nine drugs regimens observed. Premedicated, as compared to non premedicated neonates, had a higher median [IQR] gestational age (30 [28-31] vs 28 [27-30] weeks, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0215150