Chronic sleep deprivation markedly reduces coagulation factor VII expression

Chronic sleep loss, a common feature of human life in industrialized countries, is associated to cardiovascular disorders. Variations in functional parameters of coagulation might contribute to explain this relationship. By exploiting the mouse model and a specifically designed protocol, we demonstr...

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Bibliographic Details
Published in:Haematologica (Roma) 2010-08, Vol.95 (8), p.1429-1432
Main Authors: PINOTTI, Mirko, BERTOLUCCI, Cristiano, TOSINI, Gianluca, FRIGATO, Elena, BRANCHINI, Alessio, CAVALLARI, Nicola, BABA, Kenkichi, CONTRERAS-ALCANTARA, Susana, EHLEN, J. Christopher, BERNARDI, Francesco, PAUL, Ketema N
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brief Report
Chronic Disease
Factor VII - genetics
Factor VII - metabolism
Factor VIIa - metabolism
Gene Expression Regulation
Hematologic and hematopoietic diseases
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Mice
Mice, Inbred C57BL
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction
Sleep Deprivation - blood
Sleep Deprivation - physiopathology
Thrombin - metabolism
Thromboplastin - metabolism
Time Factors
Weight Loss - physiology
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Summary:Chronic sleep loss, a common feature of human life in industrialized countries, is associated to cardiovascular disorders. Variations in functional parameters of coagulation might contribute to explain this relationship. By exploiting the mouse model and a specifically designed protocol, we demonstrated that seven days of partial sleep deprivation significantly decreases (-30.5%) the thrombin generation potential in plasma evaluated upon extrinsic (TF/FVIIa pathway) but not intrinsic activation of coagulation. This variation was consistent with a decrease (-49.8%) in the plasma activity levels of factor VII (FVII), the crucial physiologicalal trigger of coagulation, which was even more pronounced at the liver mRNA level (-85.7%). The recovery in normal sleep conditions for three days completely restored thrombin generation and FVII activity in plasma. For the first time, we demonstrate that chronic sleep deprivation on its own reduces, in a reversible manner, the FVII expression levels, thus influencing the TF/FVIIa activation pathway efficiency.
ISSN:0390-6078
1592-8721
DOI:10.3324/haematol.2010.022475