Causal effects of gut microbiome on endometriosis: a two-sample mendelian randomization study

Previous studies have shown observational associations between the gut microbiota and endometriosis; however, the causal nature of such associations remains unclear. This study aimed to analyze the genetic causal relationship between the two. A gut microbiome genome-wide association study conducted...

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Bibliographic Details
Published in:BMC women's health 2023-11, Vol.23 (1), p.637-637, Article 637
Main Authors: Liu, Ziyu, Chen, Peigen, Luo, Liling, Liu, Qianru, Shi, Hao, Yang, Xing
Format: Article
Language:English
Subjects:
Causal effect
Confounding (Statistics)
Digestive system
Endometriosis
Endometriosis - genetics
Estimates
Female
Flora
Gastrointestinal Microbiome - genetics
Genome-Wide Association Study
Genomes
Gut microbiota
Heterogeneity
Humans
Mendelian Randomization Analysis
Mendelian randomization study
Microbiota
Polymorphism
Quality control
Sensitivity analysis
Statistical power
Taxonomy
Variables
Womens health
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Summary:Previous studies have shown observational associations between the gut microbiota and endometriosis; however, the causal nature of such associations remains unclear. This study aimed to analyze the genetic causal relationship between the two. A gut microbiome genome-wide association study conducted by the MiBioGen consortium was used as exposure data, and summary statistics of endometriosis were obtained from the FinnGen consortium R8 release data. Inverse variance weighted, MR-Egger, weighted median, weighted model, and simple model analyses were applied to examine the causal relationship, and sensitivity analyses were conducted to validate the robustness of the results. The results showed that, out of 211 gut microbiome taxa, Clostridiales_vadin_BB60_group, Oxalobacteraceae, Desulfovibrio, Haemophilus, and Holdemania had protective effects on endometriosis, while Porphyromonadaceae and Anaerotruncus might contribute to the development of endometriosis. Heterogeneity and pleiotropy analyses confirmed the robustness of the results. The two-sample Mendelian randomization analysis conducted in this study identified specific intestinal flora with a causal relationship with endometriosis at the genetic level, offering new insights into the gut microbiota-mediated development mechanism of endometriosis.
ISSN:1472-6874
1472-6874
DOI:10.1186/s12905-023-02742-0