Microbiota and mucosal immunity in amphibians

We know that animals live in a world dominated by bacteria. In the last 20 years, we have learned that microbes are essential regulators of mucosal immunity. Bacteria, archeas, and viruses influence different aspects of mucosal development and function. Yet, the literature mainly covers findings obt...

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Published in:Frontiers in immunology 2015-03, Vol.6, p.111-111
Main Authors: Colombo, Bruno M, Scalvenzi, Thibault, Benlamara, Sarah, Pollet, Nicolas
Format: Article
Language:English
Subjects:
Animal biology
Animal genetics
Biochemistry, Molecular Biology
Biodiversity
Cell Behavior
Cellular Biology
chytrids
Development Biology
Embryology and Organogenesis
Genetics
Genomics
Immunology
Life Sciences
microbiome
Molecular biology
Morphogenesis
mucosal immunity
Populations and Evolution
Quantitative Methods
Small-animal model
Subcellular Processes
Systematics, Phylogenetics and taxonomy
Vertebrate Zoology
Xenopus
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cited_by cdi_FETCH-LOGICAL-c562t-1ba21f020e7a1528444a2baa6036b2e6ab3600d6938a241a7d7abc5e0863f7943
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container_title Frontiers in immunology
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creator Colombo, Bruno M
Scalvenzi, Thibault
Benlamara, Sarah
Pollet, Nicolas
description We know that animals live in a world dominated by bacteria. In the last 20 years, we have learned that microbes are essential regulators of mucosal immunity. Bacteria, archeas, and viruses influence different aspects of mucosal development and function. Yet, the literature mainly covers findings obtained in mammals. In this review, we focus on two major themes that emerge from the comparative analysis of mammals and amphibians. These themes concern: (i) the structure and functions of lymphoid organs and immune cells in amphibians, with a focus on the gut mucosal immune system; and (ii) the characteristics of the amphibian microbiota and its influence on mucosal immunity. Lastly, we propose to use Xenopus tadpoles as an alternative small-animal model to improve the fundamental knowledge on immunological functions of gut microbiota.
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In the last 20 years, we have learned that microbes are essential regulators of mucosal immunity. Bacteria, archeas, and viruses influence different aspects of mucosal development and function. Yet, the literature mainly covers findings obtained in mammals. In this review, we focus on two major themes that emerge from the comparative analysis of mammals and amphibians. These themes concern: (i) the structure and functions of lymphoid organs and immune cells in amphibians, with a focus on the gut mucosal immune system; and (ii) the characteristics of the amphibian microbiota and its influence on mucosal immunity. 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subjects Animal biology
Animal genetics
Biochemistry, Molecular Biology
Biodiversity
Cell Behavior
Cellular Biology
chytrids
Development Biology
Embryology and Organogenesis
Genetics
Genomics
Immunology
Life Sciences
microbiome
Molecular biology
Morphogenesis
mucosal immunity
Populations and Evolution
Quantitative Methods
Small-animal model
Subcellular Processes
Systematics, Phylogenetics and taxonomy
Vertebrate Zoology
Xenopus
title Microbiota and mucosal immunity in amphibians
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