Role of hypoxia-induced exosomes in tumor biology

Hypoxia is a major regulator of angiogenesis and always influences the release of exosomes in various types of tumors. The present review aimed to assess the role of hypoxia-induced exosomes in the tumor biology. The relevant publications were retrieved from PubMed using keywords such as hypoxia, ex...

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Bibliographic Details
Published in:Molecular cancer 2018-08, Vol.17 (1), p.120-120, Article 120
Main Authors: Shao, Chuchu, Yang, Fengming, Miao, Suyu, Liu, Weitao, Wang, Chaoshan, Shu, Yongqian, Shen, Hua
Format: Article
Language:English
Subjects:
Analysis
Angiogenesis
Apoptosis
Biology
Body fluids
Brain tumors
Breast cancer
Cancer
Cell Hypoxia
Communication
Exosome
Exosomes
Exosomes - metabolism
Extracellular vesicles
Gene expression
Growth factors
Health aspects
Humans
Hypoxia
Hypoxia (Aquatic ecology)
Immune system
Metastases
Metastasis
MicroRNAs
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasms - metabolism
Neovascularization
Neovascularization, Pathologic - metabolism
Review
Secretion
Tumors
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Summary:Hypoxia is a major regulator of angiogenesis and always influences the release of exosomes in various types of tumors. The present review aimed to assess the role of hypoxia-induced exosomes in the tumor biology. The relevant publications were retrieved from PubMed using keywords such as hypoxia, exosome, extracellular vesicles, tumor, cancer, and other similar terms. Recent studies have shown that cancer cells produce more exosomes under hypoxic conditions than do parental cells under normoxic conditions. The secretion and function of exosomes could be influenced by hypoxia in various types of cancer. Hypoxia-induced exosomes play critical roles in tumor angiogenesis, invasion, metastasis, and the immune system. These findings provide new insights into the complex networks underlying cellular and genomic regulation in response to hypoxia and might provide novel and specific targets for future therapies.
ISSN:1476-4598
1476-4598
DOI:10.1186/s12943-018-0869-y