Towards Clinically Relevant Oculomotor Biomarkers in Early Schizophrenia

In recent years, psychiatric research has focused on the evaluation and implementation of biomarkers in the clinical praxis. Oculomotor function deviances are among the most consistent and replicable cognitive deficits in schizophrenia and have been suggested as viable candidates for biomarkers. In...

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Bibliographic Details
Published in:Frontiers in behavioral neuroscience 2021-06, Vol.15, p.688683-688683
Main Authors: Athanasopoulos, Fotios, Saprikis, Orionas-Vasilis, Margeli, Myrto, Klein, Christoph, Smyrnis, Nikolaos
Format: Article
Language:English
Subjects:
Behavioral Neuroscience
biomarker
Biomarkers
Bipolar disorder
Cognitive ability
Eye movements
first episode psychosis
Mental depression
Mental disorders
oculomotor
Psychiatric research
Psychosis
Psychotropic drugs
recent onset
Schizophrenia
ultra-high risk
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Summary:In recent years, psychiatric research has focused on the evaluation and implementation of biomarkers in the clinical praxis. Oculomotor function deviances are among the most consistent and replicable cognitive deficits in schizophrenia and have been suggested as viable candidates for biomarkers. In this narrative review, we focus on oculomotor function in first-episode psychosis, recent onset schizophrenia as well as individuals at high risk for developing psychosis. We critically discuss the evidence for the possible utilization of oculomotor function measures as diagnostic, susceptibility, predictive, monitoring, and prognostic biomarkers for these conditions. Based on the current state of research we conclude that there are not sufficient data to unequivocally support the use of oculomotor function measures as biomarkers in schizophrenia.
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2021.688683