Bifunctional antibiotic hybrids: A review of clinical candidates

Antibiotic resistance is a top threat to human health and a priority across the globe. This problematic issue is accompanied by the decline of new antibiotics in the pipeline over the past 30 years. In this context, an urgent need to develop new strategies to combat antimicrobial resistance is in gr...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in pharmacology 2023-06, Vol.14, p.1158152-1158152
Main Authors: Koh, Augustine Jing Jie, Thombare, Varsha, Hussein, Maytham, Rao, Gauri G, Li, Jian, Velkov, Tony
Format: Article
Language:English
Subjects:
antibiotic pipeline
antibiotic resistance
drug combinations
drug synthesis
hybrid antibiotics
Pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Antibiotic resistance is a top threat to human health and a priority across the globe. This problematic issue is accompanied by the decline of new antibiotics in the pipeline over the past 30 years. In this context, an urgent need to develop new strategies to combat antimicrobial resistance is in great demand. Lately, among the possible approaches used to deal with antimicrobial resistance is the covalent ligation of two antibiotic pharmacophores that target the bacterial cells through a dissimilar mode of action into a single hybrid molecule, namely hybrid antibiotics. This strategy exhibits several advantages, including better antibacterial activity, overcoming the existing resistance towards individual antibiotics, and may ultimately delay the onset of bacterial resistance. This review sheds light on the latest development of the dual antibiotic hybrids pipeline, their potential mechanisms of action, and challenges in their use.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2023.1158152