Modeling apical and basal tree contribution to orientation selectivity in a mouse primary visual cortex layer 2/3 pyramidal cell

Pyramidal neurons, a mainstay of cortical regions, receive a plethora of inputs from various areas onto their morphologically distinct apical and basal trees. Both trees differentially contribute to the somatic response, defining distinct anatomical and possibly functional sub-units. To elucidate th...

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Bibliographic Details
Published in:eLife 2023-12, Vol.12
Main Authors: Petousakis, Konstantinos-Evangelos, Park, Jiyoung, Papoutsi, Athanasia, Smirnakis, Stelios, Poirazi, Panayiota
Format: Article
Language:English
Subjects:
Action potential
Action Potentials - physiology
Animals
apical tree
basal tree
Computational neuroscience
dendrites
Dendrites - physiology
Depolarization
L 2/3
Mice
Morphology
Neuroimaging
Neurons
Neuroscience
Orientation behavior
Primary Visual Cortex
Pyramidal cells
Pyramidal Cells - physiology
pyramidal neuron model
Simulation
Sodium
Trees
Visual cortex
Visual stimuli
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Summary:Pyramidal neurons, a mainstay of cortical regions, receive a plethora of inputs from various areas onto their morphologically distinct apical and basal trees. Both trees differentially contribute to the somatic response, defining distinct anatomical and possibly functional sub-units. To elucidate the contribution of each tree to the encoding of visual stimuli at the somatic level, we modeled the response pattern of a mouse L2/3 V1 pyramidal neuron to orientation tuned synaptic input. Towards this goal, we used a morphologically detailed computational model of a single cell that replicates electrophysiological and two-photon imaging data. Our simulations predict a synergistic effect of apical and basal trees on somatic action potential generation: basal tree activity, in the form of either depolarization or dendritic spiking, is necessary for producing somatic activity, despite the fact that most somatic spikes are heavily driven by apical dendritic spikes. This model provides evidence for synergistic computations taking place in the basal and apical trees of the L2/3 V1 neuron along with mechanistic explanations for tree-specific contributions and emphasizes the potential role of predictive and attentional feedback input in these cells.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.91627