Systematic Review and Meta-analysis of Deaths Attributable to Antimicrobial Resistance, Latin America

Antimicrobial resistance is a pressing global health concern, leading to 4.95 million deaths in 2019. We conducted a systematic review and meta-analysis to assess the lethality attributed to infections caused by multidrug-resistant organisms (MDROs) in Latin America and the Caribbean. A comprehensiv...

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Bibliographic Details
Published in:Emerging infectious diseases 2023-11, Vol.29 (11), p.2335-2344
Main Authors: Ciapponi, Agustin, Bardach, Ariel, Sandoval, Maria Macarena, Palermo, Maria Carolina, Navarro, Emiliano, Espinal, Carlos, Quiros, Rodolfo
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
antimicrobial resistance
Argentina
bacteria
Caribbean region
Cohort analysis
Communicable diseases
Comorbidity
COVID-19
Drug resistance
Drug resistance in microorganisms
Drug therapy
Estimates
Evaluation
Fatalities
Global health
Hospitals
Latin America
lethality
Management
Meta-analysis
Mortality
Multidrug resistant organisms
Observational studies
Pandemics
Pathogens
Secondary data analysis
Sensitivity analysis
Software
Staphylococcus infections
Statistics
Systematic review
Systematic Review and Meta-analysis of Deaths Attributable to Antimicrobial Resistance, Latin America
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Summary:Antimicrobial resistance is a pressing global health concern, leading to 4.95 million deaths in 2019. We conducted a systematic review and meta-analysis to assess the lethality attributed to infections caused by multidrug-resistant organisms (MDROs) in Latin America and the Caribbean. A comprehensive search of major databases retrieved relevant studies from 2000–2022. We included 54 observational studies, primarily from Brazil, Argentina, and Colombia. The most commonly studied organism was methicillin-resistant Staphylococcus aureus. The overall unadjusted case fatality rate related to MDROs was 45.0%; higher adjusted lethality was observed in persons infected with MDROs than in those infected with other pathogens (adjusted odds ratio 1.93, 95% CI 1.58–2.37). A higher lethality rate was seen in patients who did not receive appropriate empirical treatment (odds ratio 2.27, 95% CI 1.44–3.56). These findings underscore the increased lethality associated with antimicrobial resistance in Latin America and the Caribbean.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2911.230753