Contribution of hypoxia inducible factor-1 during viral infections

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs the formation of an active heterodimer in the n...

Full description

Saved in:
Bibliographic Details
Published in:Virulence 2020-12, Vol.11 (1), p.1482-1500
Main Authors: Reyes, Antonia, Corrales, Nicolás, Gálvez, Nicolás M. S., Bueno, Susan M., Kalergis, Alexis M., González, Pablo A.
Format: Article
Language:English
Subjects:
Cell Hypoxia - physiology
DNA viruses
Gene Expression Regulation
Humans
Hypoxia
Hypoxia-Inducible Factor 1 - genetics
Hypoxia-Inducible Factor 1 - metabolism
normoxia
Review
RNA viruses
viral treatment
Virus Diseases - immunology
Virus Diseases - physiopathology
Virus Diseases - therapy
virus life cycle
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs the formation of an active heterodimer in the nucleus that otherwise regulates the expression of numerous genes. Importantly, HIF-1 participates in both cancer and infectious diseases unveiling new therapeutic targets for those ailments. Here, we discuss aspects related to the activation of HIF-1, the effects of this transcription factor over immune system components, as well as the involvement of HIF-1 activity in response to viral infections in humans. Although HIF-1 is currently being assessed in numerous clinical settings as a potential therapy for different diseases, up to date, there are no clinical studies evaluating the pharmacological modulation of this transcription factor as a possible new antiviral treatment. However, based on the available evidence, clinical trials targeting this molecule are likely to occur soon. In this review we discuss the role of HIF-1 in viral immunity, the modulation of HIF-1 by different types of viruses, as well as the effects of HIF-1 over their life cycle and the potential use of HIF-1 as a new target for the treatment of viral infections.
ISSN:2150-5594
2150-5608
2150-5608
DOI:10.1080/21505594.2020.1836904