Protective Effect of Phoenix dactylifera L. Seeds against Paracetamol-Induced Hepatotoxicity in Rats: A Comparison with Vitamin C

Phoenix dactylifera L. (date palm) seeds have been mentioned in the Moroccan pharmacopoeia as efficient remedies against a wide range of diseases including hepatic and gastrointestinal disorders and countless infections. The current work was performed to assess the phenolic profile and hepatoprotect...

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Bibliographic Details
Published in:TheScientificWorld 2021, Vol.2021, p.6618273-7
Main Authors: Bouhlali, Eimad Dine Tariq, Derouich, Mgal, Hmidani, Abdelbassat, Bourkhis, Bouchra, Khouya, Tarik, Filali-Zegzouti, Younes, Alem, Chakib
Format: Article
Language:English
Subjects:
Acetaminophen
Acetaminophen - antagonists & inhibitors
Acetaminophen - toxicity
Acids
Animals
Antioxidants
Ascorbic acid
Ascorbic Acid - therapeutic use
Bilirubin
Caffeic acid
Chemical and Drug Induced Liver Injury - etiology
Chemical and Drug Induced Liver Injury - prevention & control
Coumaric acid
Dosage
Drug dosages
Flavonoids
Free radicals
Free radicals (Chemistry)
Gastrointestinal diseases
Glutathione
Health aspects
Hepatotoxicity
High performance liquid chromatography
Liquid chromatography
Liver
Liver diseases
Male
Medical research
Oral administration
Oxidative stress
p-Coumaric acid
Paracetamol
Phenolic compounds
Phenols
Phoeniceae - chemistry
Phoenix dactylifera
Pits
Plant Extracts - therapeutic use
Quercetin
Rats
Rats, Wistar
Rutin
Seeds
Seeds - chemistry
Toxicity
Variance analysis
Vitamins
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Summary:Phoenix dactylifera L. (date palm) seeds have been mentioned in the Moroccan pharmacopoeia as efficient remedies against a wide range of diseases including hepatic and gastrointestinal disorders and countless infections. The current work was performed to assess the phenolic profile and hepatoprotective potential of two date seed varieties, locally known as Jihl and Majhoul, aqueous extracts against paracetamol- (PCM-) driven liver toxicity in 42 Wistar rats. The polyphenol profile was built by means of an HPLC analysis. Hepatic damage was provoked by exposing rats to PCM at a dose of 1.5 g/kg once a week. Besides PCM, Jihl and Majhoul date seed extracts (200 and 400 mg/kg) were administered orally in a day-to-day routine. Our findings showed that among the examined polyphenol compounds, p-coumaric acid, quercetin, caffeic acid, and rutin were the most abundant phytochemicals. Date pits significantly (p
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1155/2021/6618273