The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement

The purpose of this study is to explore the effects of CB2 on bone regulation during orthodontic tooth movement. Thirty male mice were allocated into 2 groups (n = 15 in each group): wild type (WT) group and CB2 knockout (CB2 ) group. Orthodontic tooth movement (OTM) was induced by applying a nickel...

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Bibliographic Details
Published in:BMC oral health 2024-01, Vol.24 (1), p.23-23, Article 23
Main Authors: Fan, Deng-Ying, Zhai, Hao-Yan, Zhao, Yuan, Qiao, Xing, Zhu, De-Chao, Liu, Hui-Juan, Liu, Chunyan
Format: Article
Language:English
Subjects:
Acid phosphatase (tartrate-resistant)
Alveolar bone
Alveolar bone remodeling
Animals
Bone density
Bone mass
Bone remodeling
Bone Remodeling - physiology
Bone Resorption
Cannabinoid CB2 receptors
Cannabinoid receptors
Cell receptors
Composite materials
Compression
Computed tomography
Dental research
Health aspects
Human mechanics
Incisors
Laboratory animals
Male
Mechanical properties
Mice
Orthodontic appliances
Orthodontics
Osteoclasts
Osteoprotegerin
Phosphatase
Physiological aspects
Receptor, Cannabinoid, CB2 - genetics
Software
Statistical analysis
Teeth
Tooth movement
Tooth Movement Techniques
TRANCE protein
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Summary:The purpose of this study is to explore the effects of CB2 on bone regulation during orthodontic tooth movement. Thirty male mice were allocated into 2 groups (n = 15 in each group): wild type (WT) group and CB2 knockout (CB2 ) group. Orthodontic tooth movement (OTM) was induced by applying a nickel-titanium coil spring between the maxillary first molar and the central incisors. There are three subgroups within the WT groups (0, 7 and 14 days) and the CB2 groups (0, 7 and 14 days). 0-day groups without force application. Tooth displacement, alveolar bone mass and alveolar bone volume were assessed by micro-CT on 0, 7 and 14 days, and the number of osteoclasts was quantified by tartrate-resistant acid phosphatase (TRAP) staining. Moreover, the expression levels of RANKL and OPG in the compression area were measured histomorphometrically. The WT group exhibited the typical pattern of OTM, characterized by narrowed periodontal space and bone resorption on the compression area. In contrast, the accelerated tooth displacement, increased osteoclast number (P 
ISSN:1472-6831
1472-6831
DOI:10.1186/s12903-023-03810-5