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The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement
The purpose of this study is to explore the effects of CB2 on bone regulation during orthodontic tooth movement. Thirty male mice were allocated into 2 groups (n = 15 in each group): wild type (WT) group and CB2 knockout (CB2 ) group. Orthodontic tooth movement (OTM) was induced by applying a nickel...
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| Published in: | BMC oral health 2024-01, Vol.24 (1), p.23-23, Article 23 |
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| creator | Fan, Deng-Ying Zhai, Hao-Yan Zhao, Yuan Qiao, Xing Zhu, De-Chao Liu, Hui-Juan Liu, Chunyan |
| description | The purpose of this study is to explore the effects of CB2 on bone regulation during orthodontic tooth movement.
Thirty male mice were allocated into 2 groups (n = 15 in each group): wild type (WT) group and CB2 knockout (CB2
) group. Orthodontic tooth movement (OTM) was induced by applying a nickel-titanium coil spring between the maxillary first molar and the central incisors. There are three subgroups within the WT groups (0, 7 and 14 days) and the CB2
groups (0, 7 and 14 days). 0-day groups without force application. Tooth displacement, alveolar bone mass and alveolar bone volume were assessed by micro-CT on 0, 7 and 14 days, and the number of osteoclasts was quantified by tartrate-resistant acid phosphatase (TRAP) staining. Moreover, the expression levels of RANKL and OPG in the compression area were measured histomorphometrically.
The WT group exhibited the typical pattern of OTM, characterized by narrowed periodontal space and bone resorption on the compression area. In contrast, the accelerated tooth displacement, increased osteoclast number (P |
| doi_str_mv | 10.1186/s12903-023-03810-5 |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_ed9b4a1d08c5427ca871b78fed59311d</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A778322481</galeid><doaj_id>oai_doaj_org_article_ed9b4a1d08c5427ca871b78fed59311d</doaj_id><sourcerecordid>A778322481</sourcerecordid><originalsourceid>FETCH-LOGICAL-c459t-c11038f288cd040bbaa68047fa092f2e50a51521dda2e2f6a2d142568bc285e23</originalsourceid><addsrcrecordid>eNptUk1r3DAQNaWlSdP-gR6KoJdenGpkyZaPIbRpINBLSo9Clka7WmzNVvYW8u8rZ5P0gyLEiOG9pzfDq6q3wM8BdPtxBtHzpuai3EYDr9Wz6hRkJ-pWN_D8j_dJ9Wqed5xDp6V8WZ0UdKcL-7T6frtFlmlERoE5m5IdYqLoWUaH-4UyEywmNlAqMJzI4xjThvlDXgvlZUue0hIdW4iWLZvoJ06YltfVi2DHGd881LPq2-dPt5df6puvV9eXFze1k6pfagdQrAehtfNc8mGwttVcdsHyXgSBilsFSoD3VqAIrRUepFCtHpzQCkVzVl0fdT3ZndnnONl8Z8hGc9-gvDE2F3sjGvT9IC14rp2SonNWdzB0OqBXfQPgi9aHo9Y-048DzouZ4uxwHG1COsxG9GXtslV9W6Dv_4Hu6JBTmXRFSaGh1-o3amPL_zEFWrJ1q6i56DrdCCE1FNT5f1DleJyiK4sPsfT_IogjwWWa54zhaW7gZk2GOSbDlGSY-2SY1cu7B8eHYUL_RHmMQvMLdB2w-w</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2914281985</pqid></control><display><type>article</type><title>The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement</title><source>Publicly Available Content (ProQuest)</source><source>PubMed Central</source><creator>Fan, Deng-Ying ; Zhai, Hao-Yan ; Zhao, Yuan ; Qiao, Xing ; Zhu, De-Chao ; Liu, Hui-Juan ; Liu, Chunyan</creator><creatorcontrib>Fan, Deng-Ying ; Zhai, Hao-Yan ; Zhao, Yuan ; Qiao, Xing ; Zhu, De-Chao ; Liu, Hui-Juan ; Liu, Chunyan</creatorcontrib><description>The purpose of this study is to explore the effects of CB2 on bone regulation during orthodontic tooth movement.
Thirty male mice were allocated into 2 groups (n = 15 in each group): wild type (WT) group and CB2 knockout (CB2
) group. Orthodontic tooth movement (OTM) was induced by applying a nickel-titanium coil spring between the maxillary first molar and the central incisors. There are three subgroups within the WT groups (0, 7 and 14 days) and the CB2
groups (0, 7 and 14 days). 0-day groups without force application. Tooth displacement, alveolar bone mass and alveolar bone volume were assessed by micro-CT on 0, 7 and 14 days, and the number of osteoclasts was quantified by tartrate-resistant acid phosphatase (TRAP) staining. Moreover, the expression levels of RANKL and OPG in the compression area were measured histomorphometrically.
The WT group exhibited the typical pattern of OTM, characterized by narrowed periodontal space and bone resorption on the compression area. In contrast, the accelerated tooth displacement, increased osteoclast number (P < 0.0001) and bone resorption on the compression area in CB2
group. Additionally, the expression of RANKL was significantly upregulated, while OPG showed low levels in the compression area of the CB2
group (P < 0.0001).
CB2 modulated OTM and bone remodeling through regulating osteoclast activity and RANKL/OPG balance.</description><identifier>ISSN: 1472-6831</identifier><identifier>EISSN: 1472-6831</identifier><identifier>DOI: 10.1186/s12903-023-03810-5</identifier><identifier>PMID: 38178129</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Acid phosphatase (tartrate-resistant) ; Alveolar bone ; Alveolar bone remodeling ; Animals ; Bone density ; Bone mass ; Bone remodeling ; Bone Remodeling - physiology ; Bone Resorption ; Cannabinoid CB2 receptors ; Cannabinoid receptors ; Cell receptors ; Composite materials ; Compression ; Computed tomography ; Dental research ; Health aspects ; Human mechanics ; Incisors ; Laboratory animals ; Male ; Mechanical properties ; Mice ; Orthodontic appliances ; Orthodontics ; Osteoclasts ; Osteoprotegerin ; Phosphatase ; Physiological aspects ; Receptor, Cannabinoid, CB2 - genetics ; Software ; Statistical analysis ; Teeth ; Tooth movement ; Tooth Movement Techniques ; TRANCE protein</subject><ispartof>BMC oral health, 2024-01, Vol.24 (1), p.23-23, Article 23</ispartof><rights>2024. The Author(s).</rights><rights>COPYRIGHT 2024 BioMed Central Ltd.</rights><rights>2024. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c459t-c11038f288cd040bbaa68047fa092f2e50a51521dda2e2f6a2d142568bc285e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2914281985?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38178129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fan, Deng-Ying</creatorcontrib><creatorcontrib>Zhai, Hao-Yan</creatorcontrib><creatorcontrib>Zhao, Yuan</creatorcontrib><creatorcontrib>Qiao, Xing</creatorcontrib><creatorcontrib>Zhu, De-Chao</creatorcontrib><creatorcontrib>Liu, Hui-Juan</creatorcontrib><creatorcontrib>Liu, Chunyan</creatorcontrib><title>The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement</title><title>BMC oral health</title><addtitle>BMC Oral Health</addtitle><description>The purpose of this study is to explore the effects of CB2 on bone regulation during orthodontic tooth movement.
Thirty male mice were allocated into 2 groups (n = 15 in each group): wild type (WT) group and CB2 knockout (CB2
) group. Orthodontic tooth movement (OTM) was induced by applying a nickel-titanium coil spring between the maxillary first molar and the central incisors. There are three subgroups within the WT groups (0, 7 and 14 days) and the CB2
groups (0, 7 and 14 days). 0-day groups without force application. Tooth displacement, alveolar bone mass and alveolar bone volume were assessed by micro-CT on 0, 7 and 14 days, and the number of osteoclasts was quantified by tartrate-resistant acid phosphatase (TRAP) staining. Moreover, the expression levels of RANKL and OPG in the compression area were measured histomorphometrically.
The WT group exhibited the typical pattern of OTM, characterized by narrowed periodontal space and bone resorption on the compression area. In contrast, the accelerated tooth displacement, increased osteoclast number (P < 0.0001) and bone resorption on the compression area in CB2
group. Additionally, the expression of RANKL was significantly upregulated, while OPG showed low levels in the compression area of the CB2
group (P < 0.0001).
CB2 modulated OTM and bone remodeling through regulating osteoclast activity and RANKL/OPG balance.</description><subject>Acid phosphatase (tartrate-resistant)</subject><subject>Alveolar bone</subject><subject>Alveolar bone remodeling</subject><subject>Animals</subject><subject>Bone density</subject><subject>Bone mass</subject><subject>Bone remodeling</subject><subject>Bone Remodeling - physiology</subject><subject>Bone Resorption</subject><subject>Cannabinoid CB2 receptors</subject><subject>Cannabinoid receptors</subject><subject>Cell receptors</subject><subject>Composite materials</subject><subject>Compression</subject><subject>Computed tomography</subject><subject>Dental research</subject><subject>Health aspects</subject><subject>Human mechanics</subject><subject>Incisors</subject><subject>Laboratory animals</subject><subject>Male</subject><subject>Mechanical properties</subject><subject>Mice</subject><subject>Orthodontic appliances</subject><subject>Orthodontics</subject><subject>Osteoclasts</subject><subject>Osteoprotegerin</subject><subject>Phosphatase</subject><subject>Physiological aspects</subject><subject>Receptor, Cannabinoid, CB2 - genetics</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Teeth</subject><subject>Tooth movement</subject><subject>Tooth Movement Techniques</subject><subject>TRANCE protein</subject><issn>1472-6831</issn><issn>1472-6831</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1r3DAQNaWlSdP-gR6KoJdenGpkyZaPIbRpINBLSo9Clka7WmzNVvYW8u8rZ5P0gyLEiOG9pzfDq6q3wM8BdPtxBtHzpuai3EYDr9Wz6hRkJ-pWN_D8j_dJ9Wqed5xDp6V8WZ0UdKcL-7T6frtFlmlERoE5m5IdYqLoWUaH-4UyEywmNlAqMJzI4xjThvlDXgvlZUue0hIdW4iWLZvoJ06YltfVi2DHGd881LPq2-dPt5df6puvV9eXFze1k6pfagdQrAehtfNc8mGwttVcdsHyXgSBilsFSoD3VqAIrRUepFCtHpzQCkVzVl0fdT3ZndnnONl8Z8hGc9-gvDE2F3sjGvT9IC14rp2SonNWdzB0OqBXfQPgi9aHo9Y-048DzouZ4uxwHG1COsxG9GXtslV9W6Dv_4Hu6JBTmXRFSaGh1-o3amPL_zEFWrJ1q6i56DrdCCE1FNT5f1DleJyiK4sPsfT_IogjwWWa54zhaW7gZk2GOSbDlGSY-2SY1cu7B8eHYUL_RHmMQvMLdB2w-w</recordid><startdate>20240104</startdate><enddate>20240104</enddate><creator>Fan, Deng-Ying</creator><creator>Zhai, Hao-Yan</creator><creator>Zhao, Yuan</creator><creator>Qiao, Xing</creator><creator>Zhu, De-Chao</creator><creator>Liu, Hui-Juan</creator><creator>Liu, Chunyan</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20240104</creationdate><title>The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement</title><author>Fan, Deng-Ying ; Zhai, Hao-Yan ; Zhao, Yuan ; Qiao, Xing ; Zhu, De-Chao ; Liu, Hui-Juan ; Liu, Chunyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-c11038f288cd040bbaa68047fa092f2e50a51521dda2e2f6a2d142568bc285e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acid phosphatase (tartrate-resistant)</topic><topic>Alveolar bone</topic><topic>Alveolar bone remodeling</topic><topic>Animals</topic><topic>Bone density</topic><topic>Bone mass</topic><topic>Bone remodeling</topic><topic>Bone Remodeling - physiology</topic><topic>Bone Resorption</topic><topic>Cannabinoid CB2 receptors</topic><topic>Cannabinoid receptors</topic><topic>Cell receptors</topic><topic>Composite materials</topic><topic>Compression</topic><topic>Computed tomography</topic><topic>Dental research</topic><topic>Health aspects</topic><topic>Human mechanics</topic><topic>Incisors</topic><topic>Laboratory animals</topic><topic>Male</topic><topic>Mechanical properties</topic><topic>Mice</topic><topic>Orthodontic appliances</topic><topic>Orthodontics</topic><topic>Osteoclasts</topic><topic>Osteoprotegerin</topic><topic>Phosphatase</topic><topic>Physiological aspects</topic><topic>Receptor, Cannabinoid, CB2 - genetics</topic><topic>Software</topic><topic>Statistical analysis</topic><topic>Teeth</topic><topic>Tooth movement</topic><topic>Tooth Movement Techniques</topic><topic>TRANCE protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fan, Deng-Ying</creatorcontrib><creatorcontrib>Zhai, Hao-Yan</creatorcontrib><creatorcontrib>Zhao, Yuan</creatorcontrib><creatorcontrib>Qiao, Xing</creatorcontrib><creatorcontrib>Zhu, De-Chao</creatorcontrib><creatorcontrib>Liu, Hui-Juan</creatorcontrib><creatorcontrib>Liu, Chunyan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection (ProQuest Medical & Health Databases)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>BMC oral health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fan, Deng-Ying</au><au>Zhai, Hao-Yan</au><au>Zhao, Yuan</au><au>Qiao, Xing</au><au>Zhu, De-Chao</au><au>Liu, Hui-Juan</au><au>Liu, Chunyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement</atitle><jtitle>BMC oral health</jtitle><addtitle>BMC Oral Health</addtitle><date>2024-01-04</date><risdate>2024</risdate><volume>24</volume><issue>1</issue><spage>23</spage><epage>23</epage><pages>23-23</pages><artnum>23</artnum><issn>1472-6831</issn><eissn>1472-6831</eissn><abstract>The purpose of this study is to explore the effects of CB2 on bone regulation during orthodontic tooth movement.
Thirty male mice were allocated into 2 groups (n = 15 in each group): wild type (WT) group and CB2 knockout (CB2
) group. Orthodontic tooth movement (OTM) was induced by applying a nickel-titanium coil spring between the maxillary first molar and the central incisors. There are three subgroups within the WT groups (0, 7 and 14 days) and the CB2
groups (0, 7 and 14 days). 0-day groups without force application. Tooth displacement, alveolar bone mass and alveolar bone volume were assessed by micro-CT on 0, 7 and 14 days, and the number of osteoclasts was quantified by tartrate-resistant acid phosphatase (TRAP) staining. Moreover, the expression levels of RANKL and OPG in the compression area were measured histomorphometrically.
The WT group exhibited the typical pattern of OTM, characterized by narrowed periodontal space and bone resorption on the compression area. In contrast, the accelerated tooth displacement, increased osteoclast number (P < 0.0001) and bone resorption on the compression area in CB2
group. Additionally, the expression of RANKL was significantly upregulated, while OPG showed low levels in the compression area of the CB2
group (P < 0.0001).
CB2 modulated OTM and bone remodeling through regulating osteoclast activity and RANKL/OPG balance.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>38178129</pmid><doi>10.1186/s12903-023-03810-5</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMC oral health, 2024-01, Vol.24 (1), p.23-23, Article 23 |
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| language | eng |
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| source | Publicly Available Content (ProQuest); PubMed Central |
| subjects | Acid phosphatase (tartrate-resistant) Alveolar bone Alveolar bone remodeling Animals Bone density Bone mass Bone remodeling Bone Remodeling - physiology Bone Resorption Cannabinoid CB2 receptors Cannabinoid receptors Cell receptors Composite materials Compression Computed tomography Dental research Health aspects Human mechanics Incisors Laboratory animals Male Mechanical properties Mice Orthodontic appliances Orthodontics Osteoclasts Osteoprotegerin Phosphatase Physiological aspects Receptor, Cannabinoid, CB2 - genetics Software Statistical analysis Teeth Tooth movement Tooth Movement Techniques TRANCE protein |
| title | The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement |
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