Prognostic value of subventricular zone involvement in relation to tumor volumes defined by fused MRI and O-(2-[ 18 F]fluoroethyl)-L-tyrosine (FET) PET imaging in glioblastoma multiforme

Subventricular zone (SVZ) involvement is associated with a dismal prognosis in patients with glioblastoma multiforme (GBM). Dual-time point (dtp) O-(2-[ F]fluoroethyl)-L-tyrosine (FET) PET/CT (PET) may be a time- and cost-effective alternative to dynamic FET PET, but its prognostic value, particular...

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Published in:Radiation oncology (London, England) England), 2019-03, Vol.14 (1), p.37-37, Article 37
Main Authors: Harat, Maciej, Małkowski, Bogdan, Roszkowski, Krzysztof
Format: Article
Language:English
Subjects:
Brain cancer
Clinical outcomes
Computed tomography
Edema
FET PET
Fluorine isotopes
Glioblastoma
Glioblastoma multiforme
Imaging biomarker
Infiltration
Irradiation
Kinetics
Magnetic resonance imaging
Markers
Medical imaging
Medical prognosis
Metastases
Mutation
NMR
Nuclear magnetic resonance
Oncology
Patients
Positron emission
Prognosis
Radiation therapy
Subventricular zone
Survival
Survival analysis
Systematic review
Tomography
Tumors
Tyrosine
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Summary:Subventricular zone (SVZ) involvement is associated with a dismal prognosis in patients with glioblastoma multiforme (GBM). Dual-time point (dtp) O-(2-[ F]fluoroethyl)-L-tyrosine (FET) PET/CT (PET) may be a time- and cost-effective alternative to dynamic FET PET, but its prognostic value, particularly with respect to SVZ involvement, is unknown. Thirty-five patients had two scans 5-15 and 50-60 min after i.v. FET injection to define tumor volumes and SVZ involvement before starting radiotherapy. Associations between clinical progression markers, MRI- and dtp FET PET-based tumor volumes, or SVZ involvement and progression-free (PFS) and overall survival (OS) were assessed in univariable and multivariable analyses. The extent of resection was not related to outcomes. Albeit non-significant, dtp FET PET detected more SVZ infiltration than MRI (60% vs. 51%, p = 0.25) and was significantly associated with poor survival (p 
ISSN:1748-717X
1748-717X
DOI:10.1186/s13014-019-1241-0