Enhanced Photosynthetic Pigment Production Using a Scaled-Up Continuously Circulated Bioreactor

Microalgae have gained attention as a promising source of chlorophylls and carotenoids in various industries. However, scaling up of conventional bubble columns presents challenges related to cell sedimentation and the presence of non-photosynthetic cells due to non-circulating zones and decreased l...

Full description

Saved in:
Bibliographic Details
Published in:Marine drugs 2023-11, Vol.21 (11), p.576
Main Authors: Lee, Won-Kyu, Ryu, Yong-Kyun, Kim, Taeho, Park, Areumi, Lee, Yeon-Ji, Sunwoo, In Yung, Koh, Eun-Jeong, Oh, Chulhong, Choi, Woon-Yong, Kang, Do-Hyung
Format: Article
Language:English
Subjects:
Algae
Antimicrobial agents
Biomass
Bioreactors
Bubble columns
Bubbles
Carotene
Carotenoids
Carotenoids - analysis
Cell culture
Cells
Chemical properties
Chlorophyll
Chlorophyll A
Culture Media
Dry weight
Flow cytometry
Food industry
Green algae
Innovations
Laboratories
Light
Microalgae
Photosynthesis
photosynthetic pigment
Photosynthetic pigments
Phytoplankton
Pigments
pilot scale
Plant pigments
Production processes
Productivity
ROSEMAX
scale-up
Scaling
Sedimentation & deposition
Tetraselmis
Tetraselmis sp
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c415t-a1a4af1a99e319746e603addf6d63efe0600974b313fd2283f43e5a028c9463
container_end_page
container_issue 11
container_start_page 576
container_title Marine drugs
container_volume 21
creator Lee, Won-Kyu
Ryu, Yong-Kyun
Kim, Taeho
Park, Areumi
Lee, Yeon-Ji
Sunwoo, In Yung
Koh, Eun-Jeong
Oh, Chulhong
Choi, Woon-Yong
Kang, Do-Hyung
description Microalgae have gained attention as a promising source of chlorophylls and carotenoids in various industries. However, scaling up of conventional bubble columns presents challenges related to cell sedimentation and the presence of non-photosynthetic cells due to non-circulating zones and decreased light accessibility, respectively. Therefore, this study aimed to evaluate the newly developed continuously circulated bioreactor ROSEMAX at both laboratory and pilot scales, compared to a conventional bubble column. There was no significant difference in the biomass production and photosynthetic pigment content of sp. cultivated at the laboratory scale ( > 0.05). However, at the pilot scale, the biomass cultured in ROSEMAX showed significantly high biomass (1.69 ± 0.11 g/L, dry weight, DW), chlorophyll- (14.60 ± 0.76 mg/g, DW), and total carotene (5.64 ± 0.81 mg/g, DW) concentrations compared to the conventional bubble column (1.17 ± 0.11 g/L, DW, 10.67 ± 0.72 mg/g, DW, 3.21 ± 0.56 mg/g, DW, respectively) ( ≤ 0.05). Flow cytometric analyses confirmed that the proportion of sp. live cells in the culture medium of ROSEMAX was 32.90% higher than that in the conventional bubble column, with a photosynthetic efficiency 1.14 times higher. These results support suggestions to use ROSEMAX as a bioreactor for industrial-scale applications.
doi_str_mv 10.3390/md21110576
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_ed9dc849b0ec4125ba8ea2c07f42c3df</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A774322889</galeid><doaj_id>oai_doaj_org_article_ed9dc849b0ec4125ba8ea2c07f42c3df</doaj_id><sourcerecordid>A774322889</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-a1a4af1a99e319746e603addf6d63efe0600974b313fd2283f43e5a028c9463</originalsourceid><addsrcrecordid>eNpdkVFvFCEUhYnR2Hb1xR9gJvHFmGyFgWGGx7qptUkTN6l9JnfhsstmBlZgHvbfi91ajeEBcvLdA4dDyDtGLzlX9PNkW8YY7Xr5gpwzKemyyv3Lf85n5CLnPaW8G5R4Tc54r5QSlJ4TfR12EAzaZr2LJeZjKDss3jRrv50wlGadop1N8TE0D9mHbQPNvYER7fLh0KxiKD7Mcc7jsVn5ZOYRSvX64mNCMCWmN-SVgzHj26d9Qe6_Xv9YfVvefb-5XV3dLY1gXVkCAwGOgVLImeqFREk5WOuklRwdUklplTeccWfbduBOcOyAtoNRQvIFuT252gh7fUh-gnTUEbx-FGLaakg11YgarbJmEGpDsV7ddhsYEFpDeydaw62rXh9PXocUf86Yi558NjiOELAG1e2g-MAHJlhFP_yH7uOcQs35SFHFZCcqdXmitvXbtA8ulgSmLouTNzGg81W_6nvBa7I6tyCfTgMmxZwTuudEjOrfjeu_jVf4_dMb5s2E9hn9UzH_BRUqpZY</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2893091654</pqid></control><display><type>article</type><title>Enhanced Photosynthetic Pigment Production Using a Scaled-Up Continuously Circulated Bioreactor</title><source>PubMed Central Free</source><source>Publicly Available Content (ProQuest)</source><creator>Lee, Won-Kyu ; Ryu, Yong-Kyun ; Kim, Taeho ; Park, Areumi ; Lee, Yeon-Ji ; Sunwoo, In Yung ; Koh, Eun-Jeong ; Oh, Chulhong ; Choi, Woon-Yong ; Kang, Do-Hyung</creator><creatorcontrib>Lee, Won-Kyu ; Ryu, Yong-Kyun ; Kim, Taeho ; Park, Areumi ; Lee, Yeon-Ji ; Sunwoo, In Yung ; Koh, Eun-Jeong ; Oh, Chulhong ; Choi, Woon-Yong ; Kang, Do-Hyung</creatorcontrib><description>Microalgae have gained attention as a promising source of chlorophylls and carotenoids in various industries. However, scaling up of conventional bubble columns presents challenges related to cell sedimentation and the presence of non-photosynthetic cells due to non-circulating zones and decreased light accessibility, respectively. Therefore, this study aimed to evaluate the newly developed continuously circulated bioreactor ROSEMAX at both laboratory and pilot scales, compared to a conventional bubble column. There was no significant difference in the biomass production and photosynthetic pigment content of sp. cultivated at the laboratory scale ( &gt; 0.05). However, at the pilot scale, the biomass cultured in ROSEMAX showed significantly high biomass (1.69 ± 0.11 g/L, dry weight, DW), chlorophyll- (14.60 ± 0.76 mg/g, DW), and total carotene (5.64 ± 0.81 mg/g, DW) concentrations compared to the conventional bubble column (1.17 ± 0.11 g/L, DW, 10.67 ± 0.72 mg/g, DW, 3.21 ± 0.56 mg/g, DW, respectively) ( ≤ 0.05). Flow cytometric analyses confirmed that the proportion of sp. live cells in the culture medium of ROSEMAX was 32.90% higher than that in the conventional bubble column, with a photosynthetic efficiency 1.14 times higher. These results support suggestions to use ROSEMAX as a bioreactor for industrial-scale applications.</description><identifier>ISSN: 1660-3397</identifier><identifier>EISSN: 1660-3397</identifier><identifier>DOI: 10.3390/md21110576</identifier><identifier>PMID: 37999400</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Algae ; Antimicrobial agents ; Biomass ; Bioreactors ; Bubble columns ; Bubbles ; Carotene ; Carotenoids ; Carotenoids - analysis ; Cell culture ; Cells ; Chemical properties ; Chlorophyll ; Chlorophyll A ; Culture Media ; Dry weight ; Flow cytometry ; Food industry ; Green algae ; Innovations ; Laboratories ; Light ; Microalgae ; Photosynthesis ; photosynthetic pigment ; Photosynthetic pigments ; Phytoplankton ; Pigments ; pilot scale ; Plant pigments ; Production processes ; Productivity ; ROSEMAX ; scale-up ; Scaling ; Sedimentation &amp; deposition ; Tetraselmis ; Tetraselmis sp</subject><ispartof>Marine drugs, 2023-11, Vol.21 (11), p.576</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c415t-a1a4af1a99e319746e603addf6d63efe0600974b313fd2283f43e5a028c9463</cites><orcidid>0000-0003-4896-1663 ; 0000-0001-7030-0082 ; 0000-0002-9283-3258 ; 0000-0001-7772-0207 ; 0009-0008-7628-3445 ; 0009-0003-6402-7712</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2893091654/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2893091654?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37999400$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Won-Kyu</creatorcontrib><creatorcontrib>Ryu, Yong-Kyun</creatorcontrib><creatorcontrib>Kim, Taeho</creatorcontrib><creatorcontrib>Park, Areumi</creatorcontrib><creatorcontrib>Lee, Yeon-Ji</creatorcontrib><creatorcontrib>Sunwoo, In Yung</creatorcontrib><creatorcontrib>Koh, Eun-Jeong</creatorcontrib><creatorcontrib>Oh, Chulhong</creatorcontrib><creatorcontrib>Choi, Woon-Yong</creatorcontrib><creatorcontrib>Kang, Do-Hyung</creatorcontrib><title>Enhanced Photosynthetic Pigment Production Using a Scaled-Up Continuously Circulated Bioreactor</title><title>Marine drugs</title><addtitle>Mar Drugs</addtitle><description>Microalgae have gained attention as a promising source of chlorophylls and carotenoids in various industries. However, scaling up of conventional bubble columns presents challenges related to cell sedimentation and the presence of non-photosynthetic cells due to non-circulating zones and decreased light accessibility, respectively. Therefore, this study aimed to evaluate the newly developed continuously circulated bioreactor ROSEMAX at both laboratory and pilot scales, compared to a conventional bubble column. There was no significant difference in the biomass production and photosynthetic pigment content of sp. cultivated at the laboratory scale ( &gt; 0.05). However, at the pilot scale, the biomass cultured in ROSEMAX showed significantly high biomass (1.69 ± 0.11 g/L, dry weight, DW), chlorophyll- (14.60 ± 0.76 mg/g, DW), and total carotene (5.64 ± 0.81 mg/g, DW) concentrations compared to the conventional bubble column (1.17 ± 0.11 g/L, DW, 10.67 ± 0.72 mg/g, DW, 3.21 ± 0.56 mg/g, DW, respectively) ( ≤ 0.05). Flow cytometric analyses confirmed that the proportion of sp. live cells in the culture medium of ROSEMAX was 32.90% higher than that in the conventional bubble column, with a photosynthetic efficiency 1.14 times higher. These results support suggestions to use ROSEMAX as a bioreactor for industrial-scale applications.</description><subject>Algae</subject><subject>Antimicrobial agents</subject><subject>Biomass</subject><subject>Bioreactors</subject><subject>Bubble columns</subject><subject>Bubbles</subject><subject>Carotene</subject><subject>Carotenoids</subject><subject>Carotenoids - analysis</subject><subject>Cell culture</subject><subject>Cells</subject><subject>Chemical properties</subject><subject>Chlorophyll</subject><subject>Chlorophyll A</subject><subject>Culture Media</subject><subject>Dry weight</subject><subject>Flow cytometry</subject><subject>Food industry</subject><subject>Green algae</subject><subject>Innovations</subject><subject>Laboratories</subject><subject>Light</subject><subject>Microalgae</subject><subject>Photosynthesis</subject><subject>photosynthetic pigment</subject><subject>Photosynthetic pigments</subject><subject>Phytoplankton</subject><subject>Pigments</subject><subject>pilot scale</subject><subject>Plant pigments</subject><subject>Production processes</subject><subject>Productivity</subject><subject>ROSEMAX</subject><subject>scale-up</subject><subject>Scaling</subject><subject>Sedimentation &amp; deposition</subject><subject>Tetraselmis</subject><subject>Tetraselmis sp</subject><issn>1660-3397</issn><issn>1660-3397</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkVFvFCEUhYnR2Hb1xR9gJvHFmGyFgWGGx7qptUkTN6l9JnfhsstmBlZgHvbfi91ajeEBcvLdA4dDyDtGLzlX9PNkW8YY7Xr5gpwzKemyyv3Lf85n5CLnPaW8G5R4Tc54r5QSlJ4TfR12EAzaZr2LJeZjKDss3jRrv50wlGadop1N8TE0D9mHbQPNvYER7fLh0KxiKD7Mcc7jsVn5ZOYRSvX64mNCMCWmN-SVgzHj26d9Qe6_Xv9YfVvefb-5XV3dLY1gXVkCAwGOgVLImeqFREk5WOuklRwdUklplTeccWfbduBOcOyAtoNRQvIFuT252gh7fUh-gnTUEbx-FGLaakg11YgarbJmEGpDsV7ddhsYEFpDeydaw62rXh9PXocUf86Yi558NjiOELAG1e2g-MAHJlhFP_yH7uOcQs35SFHFZCcqdXmitvXbtA8ulgSmLouTNzGg81W_6nvBa7I6tyCfTgMmxZwTuudEjOrfjeu_jVf4_dMb5s2E9hn9UzH_BRUqpZY</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Lee, Won-Kyu</creator><creator>Ryu, Yong-Kyun</creator><creator>Kim, Taeho</creator><creator>Park, Areumi</creator><creator>Lee, Yeon-Ji</creator><creator>Sunwoo, In Yung</creator><creator>Koh, Eun-Jeong</creator><creator>Oh, Chulhong</creator><creator>Choi, Woon-Yong</creator><creator>Kang, Do-Hyung</creator><general>MDPI AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7TN</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H95</scope><scope>H99</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.F</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4896-1663</orcidid><orcidid>https://orcid.org/0000-0001-7030-0082</orcidid><orcidid>https://orcid.org/0000-0002-9283-3258</orcidid><orcidid>https://orcid.org/0000-0001-7772-0207</orcidid><orcidid>https://orcid.org/0009-0008-7628-3445</orcidid><orcidid>https://orcid.org/0009-0003-6402-7712</orcidid></search><sort><creationdate>20231101</creationdate><title>Enhanced Photosynthetic Pigment Production Using a Scaled-Up Continuously Circulated Bioreactor</title><author>Lee, Won-Kyu ; Ryu, Yong-Kyun ; Kim, Taeho ; Park, Areumi ; Lee, Yeon-Ji ; Sunwoo, In Yung ; Koh, Eun-Jeong ; Oh, Chulhong ; Choi, Woon-Yong ; Kang, Do-Hyung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-a1a4af1a99e319746e603addf6d63efe0600974b313fd2283f43e5a028c9463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Algae</topic><topic>Antimicrobial agents</topic><topic>Biomass</topic><topic>Bioreactors</topic><topic>Bubble columns</topic><topic>Bubbles</topic><topic>Carotene</topic><topic>Carotenoids</topic><topic>Carotenoids - analysis</topic><topic>Cell culture</topic><topic>Cells</topic><topic>Chemical properties</topic><topic>Chlorophyll</topic><topic>Chlorophyll A</topic><topic>Culture Media</topic><topic>Dry weight</topic><topic>Flow cytometry</topic><topic>Food industry</topic><topic>Green algae</topic><topic>Innovations</topic><topic>Laboratories</topic><topic>Light</topic><topic>Microalgae</topic><topic>Photosynthesis</topic><topic>photosynthetic pigment</topic><topic>Photosynthetic pigments</topic><topic>Phytoplankton</topic><topic>Pigments</topic><topic>pilot scale</topic><topic>Plant pigments</topic><topic>Production processes</topic><topic>Productivity</topic><topic>ROSEMAX</topic><topic>scale-up</topic><topic>Scaling</topic><topic>Sedimentation &amp; deposition</topic><topic>Tetraselmis</topic><topic>Tetraselmis sp</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Won-Kyu</creatorcontrib><creatorcontrib>Ryu, Yong-Kyun</creatorcontrib><creatorcontrib>Kim, Taeho</creatorcontrib><creatorcontrib>Park, Areumi</creatorcontrib><creatorcontrib>Lee, Yeon-Ji</creatorcontrib><creatorcontrib>Sunwoo, In Yung</creatorcontrib><creatorcontrib>Koh, Eun-Jeong</creatorcontrib><creatorcontrib>Oh, Chulhong</creatorcontrib><creatorcontrib>Choi, Woon-Yong</creatorcontrib><creatorcontrib>Kang, Do-Hyung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oceanic Abstracts</collection><collection>ProQuest_Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Earth, Atmospheric &amp; Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science &amp; Fisheries Abstracts (ASFA) 1: Biological Sciences &amp; Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Aquatic Science &amp; Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science &amp; Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric &amp; Aquatic Science Database</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Marine drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Won-Kyu</au><au>Ryu, Yong-Kyun</au><au>Kim, Taeho</au><au>Park, Areumi</au><au>Lee, Yeon-Ji</au><au>Sunwoo, In Yung</au><au>Koh, Eun-Jeong</au><au>Oh, Chulhong</au><au>Choi, Woon-Yong</au><au>Kang, Do-Hyung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced Photosynthetic Pigment Production Using a Scaled-Up Continuously Circulated Bioreactor</atitle><jtitle>Marine drugs</jtitle><addtitle>Mar Drugs</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>21</volume><issue>11</issue><spage>576</spage><pages>576-</pages><issn>1660-3397</issn><eissn>1660-3397</eissn><abstract>Microalgae have gained attention as a promising source of chlorophylls and carotenoids in various industries. However, scaling up of conventional bubble columns presents challenges related to cell sedimentation and the presence of non-photosynthetic cells due to non-circulating zones and decreased light accessibility, respectively. Therefore, this study aimed to evaluate the newly developed continuously circulated bioreactor ROSEMAX at both laboratory and pilot scales, compared to a conventional bubble column. There was no significant difference in the biomass production and photosynthetic pigment content of sp. cultivated at the laboratory scale ( &gt; 0.05). However, at the pilot scale, the biomass cultured in ROSEMAX showed significantly high biomass (1.69 ± 0.11 g/L, dry weight, DW), chlorophyll- (14.60 ± 0.76 mg/g, DW), and total carotene (5.64 ± 0.81 mg/g, DW) concentrations compared to the conventional bubble column (1.17 ± 0.11 g/L, DW, 10.67 ± 0.72 mg/g, DW, 3.21 ± 0.56 mg/g, DW, respectively) ( ≤ 0.05). Flow cytometric analyses confirmed that the proportion of sp. live cells in the culture medium of ROSEMAX was 32.90% higher than that in the conventional bubble column, with a photosynthetic efficiency 1.14 times higher. These results support suggestions to use ROSEMAX as a bioreactor for industrial-scale applications.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37999400</pmid><doi>10.3390/md21110576</doi><orcidid>https://orcid.org/0000-0003-4896-1663</orcidid><orcidid>https://orcid.org/0000-0001-7030-0082</orcidid><orcidid>https://orcid.org/0000-0002-9283-3258</orcidid><orcidid>https://orcid.org/0000-0001-7772-0207</orcidid><orcidid>https://orcid.org/0009-0008-7628-3445</orcidid><orcidid>https://orcid.org/0009-0003-6402-7712</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1660-3397
ispartof Marine drugs, 2023-11, Vol.21 (11), p.576
issn 1660-3397
1660-3397
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_ed9dc849b0ec4125ba8ea2c07f42c3df
source PubMed Central Free; Publicly Available Content (ProQuest)
subjects Algae
Antimicrobial agents
Biomass
Bioreactors
Bubble columns
Bubbles
Carotene
Carotenoids
Carotenoids - analysis
Cell culture
Cells
Chemical properties
Chlorophyll
Chlorophyll A
Culture Media
Dry weight
Flow cytometry
Food industry
Green algae
Innovations
Laboratories
Light
Microalgae
Photosynthesis
photosynthetic pigment
Photosynthetic pigments
Phytoplankton
Pigments
pilot scale
Plant pigments
Production processes
Productivity
ROSEMAX
scale-up
Scaling
Sedimentation & deposition
Tetraselmis
Tetraselmis sp
title Enhanced Photosynthetic Pigment Production Using a Scaled-Up Continuously Circulated Bioreactor
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T10%3A43%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Enhanced%20Photosynthetic%20Pigment%20Production%20Using%20a%20Scaled-Up%20Continuously%20Circulated%20Bioreactor&rft.jtitle=Marine%20drugs&rft.au=Lee,%20Won-Kyu&rft.date=2023-11-01&rft.volume=21&rft.issue=11&rft.spage=576&rft.pages=576-&rft.issn=1660-3397&rft.eissn=1660-3397&rft_id=info:doi/10.3390/md21110576&rft_dat=%3Cgale_doaj_%3EA774322889%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c415t-a1a4af1a99e319746e603addf6d63efe0600974b313fd2283f43e5a028c9463%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2893091654&rft_id=info:pmid/37999400&rft_galeid=A774322889&rfr_iscdi=true