Nitrosyl/Diphenylphosphine/Amino Acid–Ruthenium Complexes as Inhibitors of MDA-MB-231 Breast Cancer Cells

Herein, we report on the synthesis and characterization of ruthenium compounds with the general formula [RuCl(AA-H)(NO)(dppb]PF6, where AA = glycine (1), L-alanine (2), L-phenylalanine (3) and L-valine (4), and dppb = 1,4-bis(diphenylphosphine)butane. The complexes were characterized using elemental...

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Published in:Inorganics 2023-06, Vol.11 (7), p.270
Main Authors: Barbosa, Marília I. F, Corrêa, Rodrigo S, Guedes, Adriana P. M, Graça, Alex M, Andrade, Francyelli M, Leite, Celisnólia M, Silveira-Lacerda, Elisângela P, Ellena, Javier, Reis, Henrique V, Doriguetto, Antônio C, Batista, Alzir A
Format: Article
Language:English
Subjects:
Alanine
Amino acids
Apoptosis
Breast cancer
breast cancer cells
Butane
Cancer therapies
Care and treatment
Cell death
Chemical analysis
Chemical properties
Cytotoxicity
diphenylphosphine
FDA approval
Glycine
Health aspects
Infrared analysis
L-Alanine
Ligands
nitric oxide
Nitrogen
NMR
Nuclear magnetic resonance
Phenylalanine
Phosphorus
Ruthenium
Ruthenium compounds
Single crystals
Solvents
Transition metal compounds
Valine
X-ray diffraction
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Summary:Herein, we report on the synthesis and characterization of ruthenium compounds with the general formula [RuCl(AA-H)(NO)(dppb]PF6, where AA = glycine (1), L-alanine (2), L-phenylalanine (3) and L-valine (4), and dppb = 1,4-bis(diphenylphosphine)butane. The complexes were characterized using elemental analysis, UV/Vis and infrared spectroscopies, 1H, 13C, 31P NMR techniques, and cyclic voltammetry. Furthermore, the structures of the compounds (1) and (3) were determined using single-crystal X-ray diffraction. In vitro evaluation of the Ru(II)/nitrosyl/amino acid complexes revealed their cytotoxic activities against triple-negative MDA-MB-231 breast cancer cells, and against the non-tumor murine fibroblast cells. All the compounds decreased the percentage of viable cells, inducing cell death by apoptosis. Additionally, the Ru(II) complexes inhibited the migration of MDA-MB-231 cells at concentrations lower than 35 µM, after 48 h of exposure. Thus, these complexes may be promising agents for the treatment of triple-negative MDA-MB-231 breast cancer.
ISSN:2304-6740
2304-6740
DOI:10.3390/inorganics11070270