Bilateral reaching deficits after unilateral perinatal ischemic stroke: a population-based case-control study

• Published in: Journal of neuroengineering and rehabilitation 2018-08, Vol.15 (1), p.77-77, Article 77
• Main Authors: Kuczynski, Andrea M, Kirton, Adam, Semrau, Jennifer A, Dukelow, Sean P
• Format: Article
• Language: English
• Subjects: Age; Analysis; Assessments; Brain research; Cerebral palsy; Children; Control methods; Correlation analysis; Exoskeleton; Exoskeletons; Health care facilities; Ischemia; Kinematics; Laboratories; Magnetic resonance imaging; Medical research; Motor control; Motor skills; NMR; Nuclear magnetic resonance; Paralysis; Parameters; Pediatrics; Perinatal stroke; Population; Population studies; Population-based studies; Reaching; Reaction time; Reaction time task; Robotics; Stroke; Therapeutic applications
• ISSN: 1743-0003; 1743-0003
• DOI: 10.1186/s12984-018-0420-9

Detailed kinematics of motor impairment of the contralesional ("affected") and ipsilesional ("unaffected") limbs in children with hemiparetic cerebral palsy are not well understood. We aimed to 1) quantify the kinematics of reaching in both arms of hemiparetic children with perinatal stroke using a robotic exoskeleton, and 2) assess the correlation of kinematic reaching parameters with clinical motor assessments. This prospective, case-control study involved the Alberta Perinatal Stroke Project, a population-based research cohort, and the Foothills Medical Center Stroke Robotics Laboratory in Calgary, Alberta over a four year period. Prospective cases were collected through the Calgary Stroke Program and included term-born children with magnetic resonance imaging confirmed perinatal ischemic stroke and upper extremity deficits. Control participants were recruited from the community. Participants completed a visually guided reaching task in the KINARM robot with each arm separately, with 10 parameters quantifying motor function. Kinematic measures were compared to clinical assessments and stroke type. Fifty children with perinatal ischemic stroke (28 arterial, mean age: 12.5 ± 3.9 years; 22 venous, mean age: 11.5 ± 3.8 years) and upper extremity deficits were compared to healthy controls (n = 147, mean age: 12.7 ± 3.9 years). Perinatal stroke groups demonstrated contralesional motor impairments compared to controls when reaching out (arterial = 10/10, venous = 8/10), and back (arterial = 10/10, venous = 6/10) with largest errors in reaction time, initial direction error, movement length and time. Ipsilesional impairments were also found when reaching out (arterial = 7/10, venous = 1/10) and back (arterial = 6/10). The arterial group performed worse than venous on both contralesional and ipsilesional parameters. Contralesional reaching parameters showed modest correlations with clinical measures in the arterial group. Robotic assessment of reaching behavior can quantify complex, upper limb dysfunction in children with perinatal ischemic stroke. The ipsilesional, "unaffected" limb is often abnormal and may be a target for therapeutic interventions in stroke-induced hemiparetic cerebral palsy.