Advances in Hydrogel-Based Drug Delivery Systems

Hydrogels, with their distinctive three-dimensional networks of hydrophilic polymers, drive innovations across various biomedical applications. The ability of hydrogels to absorb and retain significant volumes of water, coupled with their structural integrity and responsiveness to environmental stim...

Full description

Saved in:
Bibliographic Details
Published in:Gels 2024-04, Vol.10 (4), p.262
Main Authors: Liu, Boya, Chen, Kuo
Format: Article
Language:English
Subjects:
Biocompatibility
Biodegradation
Biomedical materials
Biopolymers
Chemistry
Crosslinking
Design
drug delivery
Drug delivery systems
Environmental engineering
Free radicals
Health aspects
Hyaluronic acid
hydrogel
Hydrogels
injectable
Innovations
ocular
oral
Physiology
Polymerization
Polymers
Regenerative medicine
Structural integrity
Tissue engineering
topical
Transdermal medication
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c490t-b78f8612c5c686be9f8a29d79e979dffaa8be5315fb0483fbe1c95215a1521fb3
cites cdi_FETCH-LOGICAL-c490t-b78f8612c5c686be9f8a29d79e979dffaa8be5315fb0483fbe1c95215a1521fb3
container_end_page
container_issue 4
container_start_page 262
container_title Gels
container_volume 10
creator Liu, Boya
Chen, Kuo
description Hydrogels, with their distinctive three-dimensional networks of hydrophilic polymers, drive innovations across various biomedical applications. The ability of hydrogels to absorb and retain significant volumes of water, coupled with their structural integrity and responsiveness to environmental stimuli, renders them ideal for drug delivery, tissue engineering, and wound healing. This review delves into the classification of hydrogels based on cross-linking methods, providing insights into their synthesis, properties, and applications. We further discuss the recent advancements in hydrogel-based drug delivery systems, including oral, injectable, topical, and ocular approaches, highlighting their significance in enhancing therapeutic outcomes. Additionally, we address the challenges faced in the clinical translation of hydrogels and propose future directions for leveraging their potential in personalized medicine and regenerative healthcare solutions.
doi_str_mv 10.3390/gels10040262
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_edb57171763a4be7ae7073270ce0c1c7</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A793069567</galeid><doaj_id>oai_doaj_org_article_edb57171763a4be7ae7073270ce0c1c7</doaj_id><sourcerecordid>A793069567</sourcerecordid><originalsourceid>FETCH-LOGICAL-c490t-b78f8612c5c686be9f8a29d79e979dffaa8be5315fb0483fbe1c95215a1521fb3</originalsourceid><addsrcrecordid>eNptkUlrHDEQhZuQEBvHt5xDQy45pB0tre048Q6GHJKchZbSoKG75Ujdhvn31mQc2zGmQBLFV--peE3zEaMTShX6toahYIR6RDh50xwSilFHJMdvn70PmuNSNgghLBhlGL9vDqjkXHCJDxu08ndmclDaOLVXW59Tley-mwK-PcvLuj2DId5B3rY_t2WGsXxo3gUzFDh-uI-a3xfnv06vupsfl9enq5vO9QrNnRUyVG_imOOSW1BBGqK8UKCE8iEYIy0wilmwqJc0WMBOMYKZwfUMlh4113tdn8xG3-Y4mrzVyUT9t5HyWps8RzeABm-ZwLU4Nb0FYUAgQYlADpDDTlStL3ut25z-LFBmPcbiYBjMBGkpmqJeKCol6yv6-QW6SUue6qY7iksiJZZP1NpU_ziFNGfjdqJ6VZUQV4zvbE9eoWp5GKNLE4RY-_8NfN0PuJxKyRAe98ZI7_LWz_Ou-KeHvy52BP8I_0uX3gMKH6Fm</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3046828818</pqid></control><display><type>article</type><title>Advances in Hydrogel-Based Drug Delivery Systems</title><source>Access via ProQuest (Open Access)</source><source>PubMed Central</source><creator>Liu, Boya ; Chen, Kuo</creator><creatorcontrib>Liu, Boya ; Chen, Kuo</creatorcontrib><description>Hydrogels, with their distinctive three-dimensional networks of hydrophilic polymers, drive innovations across various biomedical applications. The ability of hydrogels to absorb and retain significant volumes of water, coupled with their structural integrity and responsiveness to environmental stimuli, renders them ideal for drug delivery, tissue engineering, and wound healing. This review delves into the classification of hydrogels based on cross-linking methods, providing insights into their synthesis, properties, and applications. We further discuss the recent advancements in hydrogel-based drug delivery systems, including oral, injectable, topical, and ocular approaches, highlighting their significance in enhancing therapeutic outcomes. Additionally, we address the challenges faced in the clinical translation of hydrogels and propose future directions for leveraging their potential in personalized medicine and regenerative healthcare solutions.</description><identifier>ISSN: 2310-2861</identifier><identifier>EISSN: 2310-2861</identifier><identifier>DOI: 10.3390/gels10040262</identifier><identifier>PMID: 38667681</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Biocompatibility ; Biodegradation ; Biomedical materials ; Biopolymers ; Chemistry ; Crosslinking ; Design ; drug delivery ; Drug delivery systems ; Environmental engineering ; Free radicals ; Health aspects ; Hyaluronic acid ; hydrogel ; Hydrogels ; injectable ; Innovations ; ocular ; oral ; Physiology ; Polymerization ; Polymers ; Regenerative medicine ; Structural integrity ; Tissue engineering ; topical ; Transdermal medication ; Wound healing</subject><ispartof>Gels, 2024-04, Vol.10 (4), p.262</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-b78f8612c5c686be9f8a29d79e979dffaa8be5315fb0483fbe1c95215a1521fb3</citedby><cites>FETCH-LOGICAL-c490t-b78f8612c5c686be9f8a29d79e979dffaa8be5315fb0483fbe1c95215a1521fb3</cites><orcidid>0000-0002-0459-4139 ; 0000-0002-8844-8605</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3046828818/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3046828818?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38667681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Boya</creatorcontrib><creatorcontrib>Chen, Kuo</creatorcontrib><title>Advances in Hydrogel-Based Drug Delivery Systems</title><title>Gels</title><addtitle>Gels</addtitle><description>Hydrogels, with their distinctive three-dimensional networks of hydrophilic polymers, drive innovations across various biomedical applications. The ability of hydrogels to absorb and retain significant volumes of water, coupled with their structural integrity and responsiveness to environmental stimuli, renders them ideal for drug delivery, tissue engineering, and wound healing. This review delves into the classification of hydrogels based on cross-linking methods, providing insights into their synthesis, properties, and applications. We further discuss the recent advancements in hydrogel-based drug delivery systems, including oral, injectable, topical, and ocular approaches, highlighting their significance in enhancing therapeutic outcomes. Additionally, we address the challenges faced in the clinical translation of hydrogels and propose future directions for leveraging their potential in personalized medicine and regenerative healthcare solutions.</description><subject>Biocompatibility</subject><subject>Biodegradation</subject><subject>Biomedical materials</subject><subject>Biopolymers</subject><subject>Chemistry</subject><subject>Crosslinking</subject><subject>Design</subject><subject>drug delivery</subject><subject>Drug delivery systems</subject><subject>Environmental engineering</subject><subject>Free radicals</subject><subject>Health aspects</subject><subject>Hyaluronic acid</subject><subject>hydrogel</subject><subject>Hydrogels</subject><subject>injectable</subject><subject>Innovations</subject><subject>ocular</subject><subject>oral</subject><subject>Physiology</subject><subject>Polymerization</subject><subject>Polymers</subject><subject>Regenerative medicine</subject><subject>Structural integrity</subject><subject>Tissue engineering</subject><subject>topical</subject><subject>Transdermal medication</subject><subject>Wound healing</subject><issn>2310-2861</issn><issn>2310-2861</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkUlrHDEQhZuQEBvHt5xDQy45pB0tre048Q6GHJKchZbSoKG75Ujdhvn31mQc2zGmQBLFV--peE3zEaMTShX6toahYIR6RDh50xwSilFHJMdvn70PmuNSNgghLBhlGL9vDqjkXHCJDxu08ndmclDaOLVXW59Tley-mwK-PcvLuj2DId5B3rY_t2WGsXxo3gUzFDh-uI-a3xfnv06vupsfl9enq5vO9QrNnRUyVG_imOOSW1BBGqK8UKCE8iEYIy0wilmwqJc0WMBOMYKZwfUMlh4113tdn8xG3-Y4mrzVyUT9t5HyWps8RzeABm-ZwLU4Nb0FYUAgQYlADpDDTlStL3ut25z-LFBmPcbiYBjMBGkpmqJeKCol6yv6-QW6SUue6qY7iksiJZZP1NpU_ziFNGfjdqJ6VZUQV4zvbE9eoWp5GKNLE4RY-_8NfN0PuJxKyRAe98ZI7_LWz_Ou-KeHvy52BP8I_0uX3gMKH6Fm</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Liu, Boya</creator><creator>Chen, Kuo</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-0459-4139</orcidid><orcidid>https://orcid.org/0000-0002-8844-8605</orcidid></search><sort><creationdate>20240401</creationdate><title>Advances in Hydrogel-Based Drug Delivery Systems</title><author>Liu, Boya ; Chen, Kuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-b78f8612c5c686be9f8a29d79e979dffaa8be5315fb0483fbe1c95215a1521fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biocompatibility</topic><topic>Biodegradation</topic><topic>Biomedical materials</topic><topic>Biopolymers</topic><topic>Chemistry</topic><topic>Crosslinking</topic><topic>Design</topic><topic>drug delivery</topic><topic>Drug delivery systems</topic><topic>Environmental engineering</topic><topic>Free radicals</topic><topic>Health aspects</topic><topic>Hyaluronic acid</topic><topic>hydrogel</topic><topic>Hydrogels</topic><topic>injectable</topic><topic>Innovations</topic><topic>ocular</topic><topic>oral</topic><topic>Physiology</topic><topic>Polymerization</topic><topic>Polymers</topic><topic>Regenerative medicine</topic><topic>Structural integrity</topic><topic>Tissue engineering</topic><topic>topical</topic><topic>Transdermal medication</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Boya</creatorcontrib><creatorcontrib>Chen, Kuo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>SciTech Premium Collection</collection><collection>https://resources.nclive.org/materials</collection><collection>Materials science collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Gels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Boya</au><au>Chen, Kuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advances in Hydrogel-Based Drug Delivery Systems</atitle><jtitle>Gels</jtitle><addtitle>Gels</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>10</volume><issue>4</issue><spage>262</spage><pages>262-</pages><issn>2310-2861</issn><eissn>2310-2861</eissn><abstract>Hydrogels, with their distinctive three-dimensional networks of hydrophilic polymers, drive innovations across various biomedical applications. The ability of hydrogels to absorb and retain significant volumes of water, coupled with their structural integrity and responsiveness to environmental stimuli, renders them ideal for drug delivery, tissue engineering, and wound healing. This review delves into the classification of hydrogels based on cross-linking methods, providing insights into their synthesis, properties, and applications. We further discuss the recent advancements in hydrogel-based drug delivery systems, including oral, injectable, topical, and ocular approaches, highlighting their significance in enhancing therapeutic outcomes. Additionally, we address the challenges faced in the clinical translation of hydrogels and propose future directions for leveraging their potential in personalized medicine and regenerative healthcare solutions.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38667681</pmid><doi>10.3390/gels10040262</doi><orcidid>https://orcid.org/0000-0002-0459-4139</orcidid><orcidid>https://orcid.org/0000-0002-8844-8605</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2310-2861
ispartof Gels, 2024-04, Vol.10 (4), p.262
issn 2310-2861
2310-2861
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_edb57171763a4be7ae7073270ce0c1c7
source Access via ProQuest (Open Access); PubMed Central
subjects Biocompatibility
Biodegradation
Biomedical materials
Biopolymers
Chemistry
Crosslinking
Design
drug delivery
Drug delivery systems
Environmental engineering
Free radicals
Health aspects
Hyaluronic acid
hydrogel
Hydrogels
injectable
Innovations
ocular
oral
Physiology
Polymerization
Polymers
Regenerative medicine
Structural integrity
Tissue engineering
topical
Transdermal medication
Wound healing
title Advances in Hydrogel-Based Drug Delivery Systems
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T07%3A46%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Advances%20in%20Hydrogel-Based%20Drug%20Delivery%20Systems&rft.jtitle=Gels&rft.au=Liu,%20Boya&rft.date=2024-04-01&rft.volume=10&rft.issue=4&rft.spage=262&rft.pages=262-&rft.issn=2310-2861&rft.eissn=2310-2861&rft_id=info:doi/10.3390/gels10040262&rft_dat=%3Cgale_doaj_%3EA793069567%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c490t-b78f8612c5c686be9f8a29d79e979dffaa8be5315fb0483fbe1c95215a1521fb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3046828818&rft_id=info:pmid/38667681&rft_galeid=A793069567&rfr_iscdi=true