The Improvement of Skin Whitening of Phenylethyl Resorcinol by Nanostructured Lipid Carriers

Phenylethyl resorcinol (4-(1-phenylethyl)1,3-benzenediol) (PR) is a new whitening agent that has been found to have the ability to inhibit tyrosinase activity. However, the application of PR is limited by photo instability and poor solubility. PR-loaded nanostructured lipid carriers (PR-NLCs) were p...

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Bibliographic Details
Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2017-08, Vol.7 (9), p.241
Main Authors: Kim, Bo-Sik, Na, Young-Guk, Choi, Jae-Hwan, Kim, Inhye, Lee, Eunji, Kim, Sung-Yeon, Lee, Jae-Young, Cho, Cheong-Weon
Format: Article
Language:English
Subjects:
Bearing strength
Biocompatibility
cellular tyrosinase inhibition assay
Controlled release
Glycerol
Lipids
Melanoma
Nanostructure
nanostructured lipid carriers
Oils & fats
Olive oil
phenylethyl resorcinol
Polydispersity
Resorcinol
Skin
Solubility
Stability
Sustained release
topical drug delivery
Tyrosinase
Ultrasonic testing
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Summary:Phenylethyl resorcinol (4-(1-phenylethyl)1,3-benzenediol) (PR) is a new whitening agent that has been found to have the ability to inhibit tyrosinase activity. However, the application of PR is limited by photo instability and poor solubility. PR-loaded nanostructured lipid carriers (PR-NLCs) were prepared by the hot-melted ultrasonic method. Glycerol monostearate and olive oil were selected as the solid lipid and liquid lipid for considering the solubility of PR in liquid lipid and partition coefficient of PR in solid lipid, respectively. The particle size and polydispersity index of PR-NLCs were 57.9 ± 1.3 nm and 0.24 ± 0.01, respectively. The encapsulation efficiency and loading capacity of PR-NLCs were 93.1 ± 4.2% and 8.5 ± 0.4%, respectively. The stability test demonstrated that the incorporation of PR into NLCs conferred excellent physicochemical stability and photo stability for at least three months at 4 °C in the dark and 25 °C under daylight. In vitro release of PR-NLCs revealed a sustained release pattern. Cellular tyrosinase assay showed that PR-NLCs could significantly inhibit tyrosinase activity in melanoma cells, suggesting that NLCs can be used as a biocompatible nanocarrier for the effective delivery of skin whitening agents.
ISSN:2079-4991
2079-4991
DOI:10.3390/nano7090241