Syncytiotrophoblast Extracellular Vesicles From Late-Onset Preeclampsia Placentae Suppress Pro-Inflammatory Immune Response in THP-1 Macrophages

Syncytiotrophoblast derived Extracellular Vesicles (STBEV) from normal pregnancy (NP) have previously been shown to interact with circulating monocytes and B cells and induce pro-inflammatory cytokine release. Early-onset preeclampsia (EOPE) is associated with an exacerbated inflammatory response, y...

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Bibliographic Details
Published in:Frontiers in immunology 2021-06, Vol.12, p.676056-676056
Main Authors: Awoyemi, Toluwalase, Motta-Mejia, Carolina, Zhang, Wei, Kouser, Lubna, White, Kirsten, Kandzija, Neva, Alhamlan, Fatimah S., Cribbs, Adam P., Tannetta, Dionne, Mazey, Emily, Redman, Christopher, Kishore, Uday, Vatish, Manu
Format: Article
Language:English
Subjects:
Immunology
inflammation
placenta
preeclampsia
THP-1 cells
vesicles
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Summary:Syncytiotrophoblast derived Extracellular Vesicles (STBEV) from normal pregnancy (NP) have previously been shown to interact with circulating monocytes and B cells and induce pro-inflammatory cytokine release. Early-onset preeclampsia (EOPE) is associated with an exacerbated inflammatory response, yet there is little data regarding late-onset PE (LOPE) and immune function. Here, using a macrophage/monocyte cell line THP-1, we investigated the inflammatory potential of STBEV, comprising medium/large-STBEV (>200nm) and small-STBEV (
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.676056