Chemical and Microbiological Changes of Expired Platelet Concentrate

Platelets are a commonly used blood component to prevent or treat bleeding in patients with thrombocytopenia or platelet dysfunction. They are stored at room temperature (22-24°C) for five days unless specific measures are taken to extend the shelf life to seven days or more. After five days, this s...

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Bibliographic Details
Published in:International journal of general medicine 2024-04, Vol.17, p.1433-1439
Main Authors: Hakami, Nora Y, Al-Ahdal, Abdulrahman M, Al-Sulami, Afnan J, Alabbadi, Httan M, Sindi, Mamdouh M, Gholam, Kholoud A, Bayuomi, Maiman M, Qadah, Talal
Format: Article
Language:English
Subjects:
bacterial detection
Dextrose
Glucose
Microbiology
Original Research
platelet
storage extension
thrombocytopenia
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Summary:Platelets are a commonly used blood component to prevent or treat bleeding in patients with thrombocytopenia or platelet dysfunction. They are stored at room temperature (22-24°C) for five days unless specific measures are taken to extend the shelf life to seven days or more. After five days, this study evaluated platelet units' biochemical changes and bacterial growth. Platelet concentrate was collected from 30 random donors: 8 females and 22 males. The collected samples were then placed on an agitator at room temperature and tested for their pH, protein content, and glucose levels using Roche Combur 100 Test Strips. The Haemonetics eBDS™ System was used for bacterial detection. The measurements were taken on day five as the control and then repeated on days 7, 9, and 11 to observe any changes. On days 5 and 7, all parameters remained unchanged. However, glucose levels significantly changed (p=
ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S449003