Common Strategies and Factors Affecting Off-Line Breath Sampling and Volatile Organic Compounds Analysis Using Thermal Desorption-Gas Chromatography-Mass Spectrometry (TD-GC-MS)

An analysis of exhaled breath enables specialists to noninvasively monitor biochemical processes and to determine any pathological state in the human body. Breath analysis holds the greatest potential to remold and personalize diagnostics; however, it requires a multidisciplinary approach and collab...

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Bibliographic Details
Published in:Metabolites 2022-12, Vol.13 (1), p.8
Main Authors: Westphal, Kinga, Dudzik, Danuta, Waszczuk-Jankowska, Małgorzata, Graff, Beata, Narkiewicz, Krzysztof, Markuszewski, Michał Jan
Format: Article
Language:English
Subjects:
Asthma
Biomarkers
breath sampling and analysis
Breath tests
Disease
Gas chromatography
mass spectrometry
Mass spectroscopy
Metabolism
Metabolites
metabolomics
Physiology
Review
Sampling
thermal desorption
VOCs
Volatile organic compounds
volatile organic compounds (VOC)
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Summary:An analysis of exhaled breath enables specialists to noninvasively monitor biochemical processes and to determine any pathological state in the human body. Breath analysis holds the greatest potential to remold and personalize diagnostics; however, it requires a multidisciplinary approach and collaboration of many specialists. Despite the fact that breath is considered to be a less complex matrix than blood, it is not commonly used as a diagnostic and prognostic tool for early detection of disordered conditions due to its problematic sampling, analysis, and storage. This review is intended to determine, standardize, and marshal experimental strategies for successful, reliable, and especially, reproducible breath analysis.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo13010008