T1 and T2 mapping to detect chronic inflammation in cardiac magnetic resonance imaging in heart failure with reduced ejection fraction

Aims The purpose of this retrospective single‐centre study was to evaluate the non‐invasive detection of endomyocardial biopsy (EMB)‐established chronic myocardial inflammation in patients with heart failure with reduced ejection fraction (HFrEF) using T1 and T2 mapping. Methods and results The stud...

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Bibliographic Details
Published in:ESC Heart Failure 2020-10, Vol.7 (5), p.2544-2552
Main Authors: Emrich, Tilman, Hahn, Felix, Fleischmann, David, Halfmann, Moritz C., Düber, Christoph, Varga‐Szemes, Akos, Escher, Felicitas, Pefani, Evgenia, Münzel, Thomas, Schultheiss, Heinz‐Peter, Kreitner, Karl‐Friedrich, Wenzel, Philip
Format: Article
Language:English
Subjects:
Biopsy
Cardiac arrhythmia
Cardiomyopathy
Cardiovascular disease
CMR
DCM phenotype
Ejection fraction
Genotype & phenotype
Heart failure
HFrEF
Inflammation
Lymphocytes
Magnetic resonance imaging
Mapping
Original
Original s
Software
Standard deviation
Statistical analysis
Values
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Summary:Aims The purpose of this retrospective single‐centre study was to evaluate the non‐invasive detection of endomyocardial biopsy (EMB)‐established chronic myocardial inflammation in patients with heart failure with reduced ejection fraction (HFrEF) using T1 and T2 mapping. Methods and results The study population consisted of 52 retrospectively identified HFrEF patients who underwent EMB and cardiac magnetic resonance imaging at 3 Tesla. EMB was defined according to the position statement of the European Society of Cardiology and served as reference to identify inflammation in all patients. A control group of healthy volunteers with prior cardiac magnetic resonance imaging studies (n = 58) was also identified. Global and segmental T1 and T2 values as well as septal measurements and tissue heterogeneity parameters were calculated. Out of the 52 patients with HFrEF, 33 patients had myocardial inflammation detected by EMB, while 19 patients were EMB negative for inflammation. Mean left ventricular ejection fraction was 31% in both groups (P = 0.97). Global T1 and T2 values in HFrEF patients were significantly higher compared with healthy controls (T1 1275 ± 69 ms vs. 1,175 ± 44 ms, P 
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.12830