Resveratrol from Dietary Supplement to a Drug Candidate: An Assessment of Potential

Resveratrol (RVT) is a well known phyto-chemical and is widely used in dietary supplements and botanical products. It shows a wide range of pharmacological/beneficial effects. Therefore, it can be a potential candidate to be developed as phyto-pharmaceutical. Multiple diseases are reported to be tre...

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Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2022-08, Vol.15 (8), p.957
Main Authors: Khattar, Shivani, Khan, Sauban Ahmed, Zaidi, Syed Amir Azam, Darvishikolour, Mahdi, Farooq, Uzma, Naseef, Punnoth Poonkuzhi, Kurunian, Mohamed Saheer, Khan, Mohammed Zaafar, Shamim, Athar, Khan, Mohd Masih Uzzaman, Iqbal, Zeenat, Mirza, Mohd. Aamir
Format: Article
Language:English
Subjects:
Angiogenesis
anti-thrombogenic
Antioxidants
Blood platelets
Cancer
carcinogenic and anti-aging
cardioprotective
Cell cycle
Chemical properties
Clinical trials
Dietary supplements
Enzymes
Free radicals
Functional foods & nutraceuticals
Inflammation
Kinases
neuroprotective
Pharmacokinetics
Pharmacology
Physiology
Proteins
Resveratrol
Review
Testing
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Summary:Resveratrol (RVT) is a well known phyto-chemical and is widely used in dietary supplements and botanical products. It shows a wide range of pharmacological/beneficial effects. Therefore, it can be a potential candidate to be developed as phyto-pharmaceutical. Multiple diseases are reported to be treated by the therapeutic effect of RVT since it has antioxidant, anti-cancer activity and anti-inflammatory activities. It also has a major role in diabetes, arthritis, cardiac disorder and platelet aggregation etc. The major requirements are establishments regarding safety, efficacy profile and physicochemical characterization. As it is already being consumed in variable maximum daily dose, there should not be a major safety concern but the dose needs to be established for different indications. Clinical trials are also being reported in different parts of the world. Physicochemical properties of the moiety are also well reported. Moreover, due to its beneficial effect on health it leads to the development of some intellectual property in the form of patents.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph15080957