Relationship Between Non-fasting Triglycerides and Cardiovascular Disease Mortality in a 20-year Follow-up Study of a Japanese General Population: NIPPON DATA90

• Published in: Journal of Epidemiology 2022/07/05, Vol.32(7), pp.303-313
• Main Authors: Hirata, Aya, Okamura, Tomonori, Hirata, Takumi, Sugiyama, Daisuke, Ohkubo, Takayoshi, Okuda, Nagako, Kita, Yoshikuni, Hayakawa, Takehito, Kadota, Aya, Kondo, Keiko, Miura, Katsuyuki, Okayama, Akira, Ueshima, Hirotsugu
• Format: Article
• Language: English
• Subjects: Cardiovascular Disease; Cardiovascular diseases; Cholesterol; Fasting; general population; Heart diseases; High density lipoprotein; Japan; Mortality; non-fasting triglyceride; Original; Risk; Triglycerides
• ISSN: 0917-5040; 1349-9092
• DOI: 10.2188/jea.JE20200399

Background: Non-fasting triglycerides (TG) are considered a better predictor of cardiovascular disease (CVD) than fasting TG. However, the effect of non-fasting TG on fatal CVD events remains unclear. In the present study, we aimed to explore the relationship between non-fasting TG and CVD mortality in a Japanese general population.Methods: A total of 6,831 participants without a history of CVD, in which those who had a blood sampling over 8 hours or more after a meal were excluded, were followed for 18.0 years. We divided participants into seven groups according to non-fasting TG levels: ≤59 mg/dL, 60–89 mg/dL, 90–119 mg/dL, 120–149 mg/dL, 150–179 mg/dL, 180–209 mg/dL, and ≥210 mg/dL, and estimated the multivariable-adjusted hazard ratios (HRs) of each TG group for CVD mortality after adjusting for potential confounders, including high density lipoprotein cholesterol. Additionally, we performed analysis stratified by age