A case of drug-induced interstitial pneumonia caused by repeated exposure to bepridil

Abstract The patient was a 78-year-old man. In August 2007, he underwent catheter ablation for atrial fibrillation after taking bepridil for 3 weeks. Soon after the ablation, he experienced frequent atrial extrasystoles and began taking bepridil again on the day he left the hospital. Six days after...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Arrhythmia 2013-02, Vol.29 (1), p.39-42
Main Authors: Yokoi, Kensuke, Yada, Hirotaka, Yoshimoto, Daisuke, Hakuno, Daihiko, Miyazaki, Koji, Adachi, Takeshi
Format: Article
Language:English
Subjects:
Ablation
Ablation (Surgery)
Atrial fibrillation
Bacterial pneumonia
Bepridil
Cardiac arrhythmia
Cardiac patients
Cardiovascular
Catheters
Corticosteroids
Drug dosages
Drug therapy
Dyspnea
Health aspects
Heart
Heart failure
Hospitalization
Interstitial pneumonia
Lung diseases
Lymphocytes
Pleural effusion
Pneumonia
Proteins
Pulmonary arteries
Pulmonary fibrosis
Radiography
Sinuses
Surfactants
Tomography
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The patient was a 78-year-old man. In August 2007, he underwent catheter ablation for atrial fibrillation after taking bepridil for 3 weeks. Soon after the ablation, he experienced frequent atrial extrasystoles and began taking bepridil again on the day he left the hospital. Six days after discharge, he was readmitted to our hospital with dyspnea and was diagnosed with acute heart failure. The patient had no recurrence of atrial fibrillation, so the administration of bepridil was stopped. His dyspnea was eased using standard therapy for heart failure and he was discharged from our hospital. In March 2011, he had a recurrence of atrial fibrillation and was readmitted to our hospital. The administration of bepridil was initiated to defibrillate the atrial fibrillation. Although bepridil stopped the atrial fibrillation by the third day, he presented with dyspnea and fever on the fourth day. A chest radiograph showed bilateral interstitial patterns that radiated from the pulmonary hilum. He was treated for acute heart failure and bacterial pneumonia, but this was ineffective. We suspected that the interstitial pneumonia was caused by bepridil. Corticosteroid therapy dramatically improved his symptoms. This was a rare case of acute drug-induced interstitial pneumonia caused by repeated exposure to bepridil.
ISSN:1880-4276
1883-2148
DOI:10.1016/j.joa.2012.09.005