Promoting apoptosis of neutrophils and phagocytosis by macrophages: novel strategies in the resolution of inflammation

Acute inflammation is the body's response to infection or injury, characterised by the rapid infiltration of polymorphonuclear neutrophils to the site of injury followed by monocytes, which differentiate locally into macrophages. The latter are essential for the removal of effete neutrophils an...

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Bibliographic Details
Published in:Swiss medical weekly 2015-02, Vol.145 (708), p.w14056-w14056
Main Authors: Martin, Katherine R, Ohayon, Delphine, Witko-Sarsat, Veronique
Format: Article
Language:English
Subjects:
apoptosis
Apoptosis - physiology
Arthritis
Autoimmune Diseases - physiopathology
Autoimmune Diseases - therapy
Biochemistry, Molecular Biology
Humans
inflammation
Inflammation - immunology
Inflammation - physiopathology
Life Sciences
Macrophage
Macrophages - physiology
neutrophil
Neutrophils - physiology
Phagocytosis
Proliferating Cell Nuclear Antigen
vasculitis
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Summary:Acute inflammation is the body's response to infection or injury, characterised by the rapid infiltration of polymorphonuclear neutrophils to the site of injury followed by monocytes, which differentiate locally into macrophages. The latter are essential for the removal of effete neutrophils and provided that the harmful agent is eliminated, removal of neutrophils will lead to the resolution of inflammation. Perturbations in this process result in the persistence of inflammation and close control of pathways associated with resolution are necessary to avoid chronic inflammation, autoimmunity, or both. As our understanding of these processes increase, drugs able to trigger pro-resolution pathways may represent an effective strategy for treating chronic inflammatory diseases.
ISSN:1424-7860
1424-3997
DOI:10.4414/smw.2015.14056