Correlation of Urinary Neutrophil Gelatinase with the Histopathological Extent of Kidney Damage in Patients with Diabetic Nephropathy

Diabetic nephropathy (DN), a leading cause of chronic kidney disease, is known to develop in around 40% of patients with diabetes. NGAL, a biomarker expressed by the tubular epithelium, has been evaluated in both acute and chronic kidney injury. However, kidney damage revealed by the histology of re...

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Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation 2023-12, Vol.34 (Suppl 1), p.S112-S121
Main Authors: Garg, Priya, Shetty, Manjunath, Krishnamurthy, Vani
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - urine
Biopsy
Diabetes
Diabetic Nephropathies - pathology
Diabetic Nephropathies - urine
Diabetic nephropathy
Female
Humans
Kidney - pathology
Lipocalin-2 - urine
Male
Middle Aged
Prospective Studies
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Summary:Diabetic nephropathy (DN), a leading cause of chronic kidney disease, is known to develop in around 40% of patients with diabetes. NGAL, a biomarker expressed by the tubular epithelium, has been evaluated in both acute and chronic kidney injury. However, kidney damage revealed by the histology of renal tissue core biopsies has not been quantified by morphometry and its correlation with urinary NGAL (uNGAL) has not been studied. Our objective was to compare levels of uNGAL with the extent of kidney damage in the histopathological results of morphometry in patients with DN. This prospective analytical study was conducted in a tertiary hospital. Urine samples of 42 patients were collected and freeze-dried. uNGAL was estimated through a chemiluminescent microparticle immunoassay. Pearson's correlation coefficients between kidney damage quantified by morphometry and NGAL values were examined. The correlation of uNGAL with the percentage of acute tubular injury assessed by morphometry in the renal core was 7.35% (P = 0.64). uNGAL had the highest correlation with inflammation (r = 54.2%; P = 0.002). Another parameter with a significant correlation was glomerular sclerosis with r = 35.6% (95% confidence interval: 10%-60%) and an associated P = 0.02. UNGAL was strongly correlated with inflammatory kidney damage in patients with DN.
ISSN:1319-2442
2320-3838
DOI:10.4103/sjkdt.sjkdt_95_22