Test-Retest Reproducibility of Reduced-Field-of-View Density-Weighted CRT MRSI at 3T

Quantifying an imaging modality's ability to reproduce results is important for establishing its utility. In magnetic resonance spectroscopic imaging (MRSI), new acquisition protocols are regularly introduced which improve upon their precursors with respect to signal-to-noise ratio (SNR), total...

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Bibliographic Details
Published in:Tomography (Ann Arbor) 2024-03, Vol.10 (4), p.493-503
Main Authors: Farley, Nicholas, Susnjar, Antonia, Chiew, Mark, Emir, Uzay E
Format: Article
Language:English
Subjects:
Adult
Brain - diagnostic imaging
Female
Glutamine
Gray Matter - diagnostic imaging
Humans
imaging
magnetic
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy - methods
Male
non-Cartesian
nuclear
Reproducibility of Results
resonance
Signal-To-Noise Ratio
spectroscopy
White Matter - diagnostic imaging
Young Adult
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Summary:Quantifying an imaging modality's ability to reproduce results is important for establishing its utility. In magnetic resonance spectroscopic imaging (MRSI), new acquisition protocols are regularly introduced which improve upon their precursors with respect to signal-to-noise ratio (SNR), total acquisition duration, and nominal voxel resolution. This study has quantified the within-subject and between-subject reproducibility of one such new protocol (reduced-field-of-view density-weighted concentric ring trajectory (rFOV-DW-CRT) MRSI) by calculating the coefficient of variance of data acquired from a test-retest experiment. The posterior cingulate cortex (PCC) and the right superior corona radiata (SCR) were selected as the regions of interest (ROIs) for grey matter (GM) and white matter (WM), respectively. CVs for between-subject and within-subject were consistently around or below 15% for Glx, tCho, and Myo-Ins, and below 5% for tNAA and tCr.
ISSN:2379-139X
2379-1381
2379-139X
DOI:10.3390/tomography10040038