Intrinsic Brain Functional Activity Abnormalities in Episodic Tension-Type Headache

Objective. The neurobiological basis of episodic tension-type headache (ETTH) remains largely unclear. The aim of the present study was to explore intrinsic brain functional activity alterations in ETTH. Methods. Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from...

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Published in:Journal of neural transplantation & plasticity 2023-05, Vol.2023, p.6560298-6
Main Authors: Yang, Xiu, Guo, DianXuan, Huang, Wei, Chen, Bing
Format: Article
Language:English
Subjects:
Age
Brain
Brain - diagnostic imaging
Brain Mapping - methods
Chronic pain
Fourier transforms
Gender
Gyrus Cinguli - diagnostic imaging
Headaches
Humans
Illnesses
Insular Cortex
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Pathophysiology
Somatotropin
Tension headache
Tension-Type Headache - diagnostic imaging
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Guo, DianXuan
Huang, Wei
Chen, Bing
description Objective. The neurobiological basis of episodic tension-type headache (ETTH) remains largely unclear. The aim of the present study was to explore intrinsic brain functional activity alterations in ETTH. Methods. Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 32 patients with ETTH and 32 age- and gender-matched healthy controls (HCs). Differences in intrinsic brain functional activity between patients with ETTH and HCs were analyzed utilizing the fractional amplitude of low-frequency fluctuation (fALFF) approach. Correlation analyses were performed to examine the relationship between fALFF alterations and clinical characteristics. Results. Compared to HCs, patients with ETTH exhibited increased fALFF in the right posterior insula and anterior insula and decreased fALFF in the posterior cingulate cortex. Moreover, the fALFF in the right anterior insula was negatively correlated with attack frequency in ETTH. Conclusions. This study highlights alterations in the intrinsic brain functional activity in the insula and posterior cingulate cortex in ETTH that can help us understand its neurobiological underpinnings.
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The neurobiological basis of episodic tension-type headache (ETTH) remains largely unclear. The aim of the present study was to explore intrinsic brain functional activity alterations in ETTH. Methods. Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 32 patients with ETTH and 32 age- and gender-matched healthy controls (HCs). Differences in intrinsic brain functional activity between patients with ETTH and HCs were analyzed utilizing the fractional amplitude of low-frequency fluctuation (fALFF) approach. Correlation analyses were performed to examine the relationship between fALFF alterations and clinical characteristics. Results. Compared to HCs, patients with ETTH exhibited increased fALFF in the right posterior insula and anterior insula and decreased fALFF in the posterior cingulate cortex. Moreover, the fALFF in the right anterior insula was negatively correlated with attack frequency in ETTH. Conclusions. This study highlights alterations in the intrinsic brain functional activity in the insula and posterior cingulate cortex in ETTH that can help us understand its neurobiological underpinnings.</description><identifier>ISSN: 2090-5904</identifier><identifier>ISSN: 0792-8483</identifier><identifier>EISSN: 1687-5443</identifier><identifier>DOI: 10.1155/2023/6560298</identifier><identifier>PMID: 37266410</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Age ; Brain ; Brain - diagnostic imaging ; Brain Mapping - methods ; Chronic pain ; Fourier transforms ; Gender ; Gyrus Cinguli - diagnostic imaging ; Headaches ; Humans ; Illnesses ; Insular Cortex ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Pathophysiology ; Somatotropin ; Tension headache ; Tension-Type Headache - diagnostic imaging</subject><ispartof>Journal of neural transplantation &amp; plasticity, 2023-05, Vol.2023, p.6560298-6</ispartof><rights>Copyright © 2023 Xiu Yang et al.</rights><rights>COPYRIGHT 2023 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2023 Xiu Yang et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023 Xiu Yang et al. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c613t-9f6379944f2d7a59a4dccb19b4a2c5e9db7d9f0b51e18bc6da5e8f678e1fc17b3</citedby><cites>FETCH-LOGICAL-c613t-9f6379944f2d7a59a4dccb19b4a2c5e9db7d9f0b51e18bc6da5e8f678e1fc17b3</cites><orcidid>0000-0002-7042-8614</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2822118461/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2822118461?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,44569,53769,53771,74872</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37266410$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cavaliere, Carlo</contributor><contributor>Carlo Cavaliere</contributor><creatorcontrib>Yang, Xiu</creatorcontrib><creatorcontrib>Guo, DianXuan</creatorcontrib><creatorcontrib>Huang, Wei</creatorcontrib><creatorcontrib>Chen, Bing</creatorcontrib><title>Intrinsic Brain Functional Activity Abnormalities in Episodic Tension-Type Headache</title><title>Journal of neural transplantation &amp; plasticity</title><addtitle>Neural Plast</addtitle><description>Objective. The neurobiological basis of episodic tension-type headache (ETTH) remains largely unclear. The aim of the present study was to explore intrinsic brain functional activity alterations in ETTH. Methods. Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 32 patients with ETTH and 32 age- and gender-matched healthy controls (HCs). Differences in intrinsic brain functional activity between patients with ETTH and HCs were analyzed utilizing the fractional amplitude of low-frequency fluctuation (fALFF) approach. Correlation analyses were performed to examine the relationship between fALFF alterations and clinical characteristics. Results. Compared to HCs, patients with ETTH exhibited increased fALFF in the right posterior insula and anterior insula and decreased fALFF in the posterior cingulate cortex. Moreover, the fALFF in the right anterior insula was negatively correlated with attack frequency in ETTH. Conclusions. This study highlights alterations in the intrinsic brain functional activity in the insula and posterior cingulate cortex in ETTH that can help us understand its neurobiological underpinnings.</description><subject>Age</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain Mapping - methods</subject><subject>Chronic pain</subject><subject>Fourier transforms</subject><subject>Gender</subject><subject>Gyrus Cinguli - diagnostic imaging</subject><subject>Headaches</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Insular Cortex</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Pathophysiology</subject><subject>Somatotropin</subject><subject>Tension headache</subject><subject>Tension-Type Headache - diagnostic imaging</subject><issn>2090-5904</issn><issn>0792-8483</issn><issn>1687-5443</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9ks2LEzEYhwdR3Lp68ywDgizo7CaZfExO0l123cKCB-s5vJOPNmWa1MnMSv97U1vLVkRySEie9wn55S2KtxhdYszYFUGkvuKMIyKbZ8UE80ZUjNL6eTEhSKKKSUTPilcprRCinDH2sjirBeGcYjQpvs3C0PuQvC6ve_ChvBuDHnwM0JXTvHj0w7actiH2a-j84G0qM3S78SmaXDO3uTSGar7d2PLeggG9tK-LFw66ZN8c5vPi-93t_Oa-evj6ZXYzfag0x_VQScdrISWljhgBTAI1WrdYthSIZlaaVhjpUMuwxU2ruQFmG8dFY7HTWLT1eTHbe02Eldr0fg39VkXw6vdG7BcK-sHrziprMTAwwmUNdRpBWxOS3QY7VgNz2fV579qM7doabXMs0J1IT0-CX6pFfFQ4x08wktlwcTD08cdo06DWPmnbdRBsHJMiDSG1qCkXGX3_F7qKY58j31MYNzQndKQWkF_gg4v5Yr2TqqlgWFDKJcnU5T-oPIxdex2DdT7vnxR8eFKwtNANyxS7cffp6RT8tAd1H1PqrTumgZHatZ7atZ46tF7G3z1N8Aj_6bUMfNwDSx8M_PT_1_0CohzfuQ</recordid><startdate>20230524</startdate><enddate>20230524</enddate><creator>Yang, Xiu</creator><creator>Guo, DianXuan</creator><creator>Huang, Wei</creator><creator>Chen, Bing</creator><general>Hindawi</general><general>John Wiley &amp; 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plasticity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Xiu</au><au>Guo, DianXuan</au><au>Huang, Wei</au><au>Chen, Bing</au><au>Cavaliere, Carlo</au><au>Carlo Cavaliere</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrinsic Brain Functional Activity Abnormalities in Episodic Tension-Type Headache</atitle><jtitle>Journal of neural transplantation &amp; plasticity</jtitle><addtitle>Neural Plast</addtitle><date>2023-05-24</date><risdate>2023</risdate><volume>2023</volume><spage>6560298</spage><epage>6</epage><pages>6560298-6</pages><issn>2090-5904</issn><issn>0792-8483</issn><eissn>1687-5443</eissn><abstract>Objective. The neurobiological basis of episodic tension-type headache (ETTH) remains largely unclear. The aim of the present study was to explore intrinsic brain functional activity alterations in ETTH. Methods. Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 32 patients with ETTH and 32 age- and gender-matched healthy controls (HCs). Differences in intrinsic brain functional activity between patients with ETTH and HCs were analyzed utilizing the fractional amplitude of low-frequency fluctuation (fALFF) approach. Correlation analyses were performed to examine the relationship between fALFF alterations and clinical characteristics. Results. Compared to HCs, patients with ETTH exhibited increased fALFF in the right posterior insula and anterior insula and decreased fALFF in the posterior cingulate cortex. Moreover, the fALFF in the right anterior insula was negatively correlated with attack frequency in ETTH. Conclusions. This study highlights alterations in the intrinsic brain functional activity in the insula and posterior cingulate cortex in ETTH that can help us understand its neurobiological underpinnings.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>37266410</pmid><doi>10.1155/2023/6560298</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-7042-8614</orcidid><oa>free_for_read</oa></addata></record>
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subjects Age
Brain
Brain - diagnostic imaging
Brain Mapping - methods
Chronic pain
Fourier transforms
Gender
Gyrus Cinguli - diagnostic imaging
Headaches
Humans
Illnesses
Insular Cortex
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Pathophysiology
Somatotropin
Tension headache
Tension-Type Headache - diagnostic imaging
title Intrinsic Brain Functional Activity Abnormalities in Episodic Tension-Type Headache
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